Aristotle (4th century B.C.) defined pain as emotion, being the opposite of pleasure. Whereas, Buddha stated "Pain is the outcome of sin", as evidence that an individual was possessed by demons. In some religions it is the cost of attachment. Spiritual counseling thus may be more of a preference than medical management. Many non-physiologic factors (psychological, familial and societal attitudes, life stressors, and cultural or spiritual) contributing to the experience of and response to pain. Emotional stress, for example, anxiety and depression assume a key job in understanding of agony. Endless agony is related with expanded dimensions of burdensome side effects, anxiety, and insomnia paying little heed to disability status. it has both modifiable factors (mental health, co-morbidities, smoking, alcohol, obesity, physical activity/exercise, sleep, nutrition, economic status and occupational) and non-modifiable factors (age, sex, cultural and socioeconomic background, history of trauma/ injury/ interpersonal violence, heritage). The relationship between increased BMI and chronic pain in adults seems intuitive and may be related, in part, to increased weight-bearing on joints, reduced physical activity and deconditioning. Patient with physical disabilities may have co-occurring chronic pain, but the prevalence and specific associated factors are unknown. Neuropathic pain (NeP) can be the result of a variety of conditions, including metabolic disease, infection, malignancy, trauma, medications, and toxins; estimates of 60% among those with chronic pain. Chronic pain affects 20% of the European population and is commoner in women, older people, and with relative deprivation. Its administration in the network remains commonly unacceptable, somewhat as a result of absence of proof for successful intercessions. Additionally, family and guardians' convictions and demeanors towards torment, either decidedly and contrarily to endure and express torment are imperative. Hazard factors incorporate socio-demographic, clinical, psychological, and biological factors. Pain increases depression risk 3-5-fold. Pain, rather than chronic disease, is associated with the recurrence of depressive and anxiety disorders; 50-80% of chronic pain patients report insomnia of a severity that warrants clinical attention. It is estimated that approximately one in five of the adult population in Europe suffers chronic pain, which is therefore more prevalent than asthma or diabetes. Chronic pain has long-term biological, psychological and social causes and consequences that are important in prevention and management.