Article

Temporal Course of Change of Depression

Department of Psychiatry and Behavioral Sciences, University of Oklahoma Health Sciences Center.
Journal of Consulting and Clinical Psychology (Impact Factor: 4.85). 11/1993; 61(5):858-64. DOI: 10.1037/0022-006X.61.5.858
Source: PubMed

ABSTRACT

Two hundred fifty moderately to severely depressed outpatients were randomly assigned to 16 weeks of cognitive-behavioral therapy, interpersonal psychotherapy, imipramine plus clinical management (IMI-CM), or pill placebo plus clinical management. Two hundred thirty-nine patients actually began treatment. The most rapid change in depressive symptoms occurred in the IMI-CM condition, which achieved significantly better results than the other treatments at 8 and 12 weeks on 1 or more variables. Change over the course of treatment on variables hypothesized to be most specifically affected by the respective treatments was found only in the case of pharmacotherapy, in which imipramine produced significantly greater changes on the endogenous measure at 8 and 12 weeks.

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    • "O'Hara, 2000 Dobkin, 2011 Grote, 2009 Mynors-Wallis, 1995 Berger, 2011 Fledderus, 2012 ACT-E Watt, 2000 Iteg Fledderus, 2012 ACT-M Scott, 2000 Choi, 2012 Harley, 2008 Vitriol, 2009 Miller, 2002 Watkins, 1993 IPT Serfaty, 2009 Dowrick, 2000 PST Laidlaw, 2008 Watkins, 1993 CBT Ward, 2000 NDC Van Schaik, 2006 Perini, 2009 Miranda, 2003 Dowrick, 2000 CWD Ward, 2001 CBT Talbot, 2011 Haringsma, 2006 Allart-van Dam, 2003 Simpson, 2003 Lynch, 2004 Neugebauer, 2006 Klein, 1985 "
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    Full-text · Article · Jan 2014 · Psychological Medicine
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    • "In studies in which Cognitive Behavior Therapy (CBT) is contrasted with antidepressants, antidepressants sometimes achieve response rates faster, but by the end of the study outcomes equalize (Blackburn & Moore, 1997; Elkin et al., 1989; Shea et al., 1992; Simons, Murphy, Levine, & Wetzel, 1986; Watkins et al., 1993). A meta-analysis examining comparative efficacy of CBT versus drugs for the severely depressed found no difference in efficacy, although effect sizes were greater for the CBT group (DeRubeis, Gelfand, Tang, Simons, 1999). "
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    • "For example, a meta-analysis of a large sample of individuals (n = 2,431) pooled from numerous psychotherapy studies found that half of the patients studied achieved symptom relief within eight sessions of open-ended treatment (Howard et al. 1986). Conventional wisdom suggests that pharmacotherapy alleviates depressive symptoms more quickly than psychotherapy (Watkins et al. 1993). However, it is possible that patients and therapists work harder and faster when the number of psychotherapy sessions is limited from the outset (Reynolds et al. 1996), thereby hastening the onset of psychotherapy's antidepressant effects. "
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