Chemoprevention of Rat Liver Carcinogenesis by S-Adenosyl-L-Methionine: Is DNA Methylation Involved?

Istituto di Patologia Generale dell'Università di Sassari, Italy.
Basic life sciences 02/1993; 61:219-37. DOI: 10.1007/978-1-4615-2984-2_20
Source: PubMed


The best approach to the control of cancer incidence in a population at risk is the removal of the causative agent (primary prevention). However, when primary prevention cannot be applied, the occurrence of cancer can be prevented by administration, to populations at risk, of one or more chemical compounds (chemoprevention; Ref. 1–3). These compounds could interfere with cancer initiation by preventing the formation of ultimate carcinogens and carcinogen-DNA adducts, or by preventing carcinogens from reaching or reacting with critical targets. Once initiation occurs, chemopreventive agents may be used to kill preneoplastic cells or suppress their evolution to neoplastic cells. This latter goal could be reached by inducing preneoplastic cells to differentiate so that they remain viable but irreversibly lose their proliferative potential.

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