Memory impairment in Cushing's disease

Department of Neurology, IRCCS C. Mondino, University of Pavia, Italy.
Acta Neurologica Scandinavica (Impact Factor: 2.4). 02/1993; 87(1):52-5. DOI: 10.1111/j.1600-0404.1993.tb04075.x
Source: PubMed


In the present study the cognitive performance of 25 patients with Cushing's disease (CD) was extensively evaluated in comparison with normal control subjects, matched one by one. The results indicate a selective impairment of memory functions: the number of patients showing a significantly impaired mnesic performance increases with age. Moreover, the neuropsychological impairment tends to recover in those cases who underwent further controls after surgical treatment. The neuropsychological data are discussed in the light of recent evidence in the literature concerning the effects of adrenal steroids on the brain.

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Available from: Roberto Attanasio
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    • "On the other hand, another study [39] concluded that, generally speaking, increased cortisol levels due to stress-induced HPA axis over activity have been associated with cognitive impairment as stress-induced HPA axis overactivity and increased cortisol levels may cause hippocampal damage and, subsequently, cognitive decline. Furthermore, patients with Cushing's syndrome more often present with cognitive impairment [40]. Finally, one of the side-effects of treatment with synthetic corticosteroids is cognitive deterioration [41] "
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    • "man & Cutler , 1995 ) show reduced hippo - campal volume . Moreover , patients suffering from Cushing ' s disease suffer from explicit declarative memory deficits , as evidenced by landmark studies of Monica Starkman and co - workers ( e . g . , Starkman & Schteingart , 1981 ; Starkman , Giordani , Berent , Schork , & Schteingart , 2001 ; see also Mauri et al . , 1993 ) . It should be noted , however , that surgical treatment of Cushing ' s disease leads to a rapid normalization of cortisol levels . More importantly , memory im - pairments also disappear and hippocampal volume normalizes ( Starkman , Giordani , Gebarski , Berent , Schork , & Schteingart , 1999 ; Starkman , Giordani , Ge - barski , & "
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