Erythroid transcription factor NF-E2 is hematopoietic-specific basic leucine zipper protein
Harvard University, Cambridge, Massachusetts, United StatesNature (Impact Factor: 41.46). 05/1993; 362(6422):722-8. DOI: 10.1038/362722a0
Expression of globin genes in developing erythroid cells is controlled by upstream locus control regions. Activity of these regions in vivo requires an erythroid-specific nuclear factor (NF-E2) that binds AP-1-like recognition sites. Its tissue-specific component (p45 NF-E2) has been characterized by complementary DNA cloning as a new basic region-leucine zipper protein which dimerizes with a ubiquitous partner to form native NF-E2.
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