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Influence of dietary curcumin and cholesterol on the progression of experimentally induced diabetes in albino rat

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  • CSIR - Central Food Technological Research Institute

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Effect of feeding 0.5% curcumin diet or 1% cholesterol diet was examined in albino rats rendered diabetic with streptozotocin injection. Diabetic rats maintained on curcumin diet for 8 weeks excreted comparatively less amounts of albumin, urea, creatinine and inorganic phosphorus. Urinary excretion of the electrolytes sodium and potassium were also significantly lowered under curcumin treatment. Dietary curcumin also partially reversed the abnormalities in plasma albumin, urea, creatine and inorganic phosphorus in diabetic animals. On the other hand, glucose excretion or the fasting sugar level was unaffected by dietary curcumin and so also the body weights were not improved to any significant extent. Diabetic rats fed curcumin diet had a lowered relative liver weight at the end of the study compared to other diabetic groups. Diabetic rats fed a curcumin diet also showed lowered lipid peroxidation in plasma and urine when compared to other diabetic groups. The extent of lipid peroxidation on the other hand, was still higher in cholesterol fed diabetic groups compared to diabetic rats fed with control diet. Thus, the study reveals that curcumin feeding improves the metabolic status in diabetic conditions, despite no effect on hyperglycemic status or the body weights. The mechanism by which curcumin improves this situation is probably by virtue of its hypocholesterolemic influence, antioxidant nature and free radical scavenging property.
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... Diabetic individuals often suffer from fatty liver disease and other liver disorders (26). Studies have shown that dietary supplementation with curcumin reduces albumin, urea, creatinine, and inorganic phosphorus excretion in streptozotocin-induced diabetic rats (27,28). Additionally, curcumin supplementation decreases liver weight, and lipid peroxidation products in plasma, and urine, independent of changes in glycemia or body weight (29). ...
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... Curcumin was used in China and India to treat some diseases (9). Fundamental studies on the medicinal properties of curcumin have shown its effect on lowering blood sugar (10)(11)(12), anti-in ammation - (2), and antioxidant properties (13) of turmeric (2). Aging and metabolic syndrome are associated with increased chronic in ammation (1). ...
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... In multiple cultures, okra mucilage is used for different medical purposes such as dysentery and diarrhea in acute inflammation and irritation of the stomach, bowels, and as a diuretic in kidneys catarrhal infections, urine ardor, dysuria, and gonorrhea. Furthermore, the seeds of okra have antispasmodic, cordial, and stimulant effects (Babu & Srinivasan, 1995;Lim, 2012). However, okra can be used in different forms, including fried, boiled, and cooked (Akintoye et al., 2011). ...
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