Lipid and lipoprotein changes in women following 6 months of exercise training in a worksite fitness program

Department of Health and Kinesiology, Applied Exercise Science Laboratory Texas A&M University, College Station 77843-4243, USA.
The Journal of sports medicine and physical fitness (Impact Factor: 0.97). 04/1996; 36(1):54-9.
Source: PubMed


It was the purpose of this investigation to examine the influence of a worksite aerobic training program on serum lipid and lipoproteins and cardiovascular fitness in female employees. Thirty-seven healthy but previously untrained, female employees (Ss) from Westinghouse Corporation, (College Station, Texas) volunteered for the study. Ss were randomly assigned to either an exercise group (Ex) (n = 20) or control group (C) (n = 17). Prior to training (PRE) and following training (POST), all Ss were measured for weight (WT), body composition (%FAT) and tested for maximal oxygen consumption (VO2 max). PRE and POST Lipid analysis included: total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C), and triglycerides (TG). Following PRE testing, the Ex group aerobically trained by walking, jogging and/or cycling, at least 3 days per wk for 24 wks. Exercise training resulted in an improvement in VO2 max (p < 0.0006) and a 2 kg WT loss in Ex (p < 0.025) with no change in C. Both Ex and C Ss exhibited a loss in %-FAT (p < 0.0001), and a decrease in TC (p < 0.0001) and LDL-C (p < 0.0001). No differences were observed between groups or over the training period for VLDL-C or TG. Although HDL-C increased 6 mg/dl in the Ex group but not in C, this difference did not reach statistical significance (p < 0.0625). These results demonstrate that aerobic training by females in a worksite fitness program significantly improves cardiovascular fitness without altering lipids or lipoproteins.

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Available from: Peter Walter Grandjean, Apr 24, 2014
    • "Many factors, like diet, smoking and physical activity , influence levels of inflammatory biomarkers and the lipoprotein profile both separately and in combinations , as described in previous literature (Grandjean et al. 1996; Pedersen and Saltin 2006). Also, aerobic exercise has been previously shown to effectively reduce levels of inflammation biomarkers (Okita et al. 2004; Loprinzi et al. 2013; Plaisance and Grandjean 2006; Kasapis and Thompson 2005) and thereby risk of cardiovascular disease (Danesh et al. 2005; Kaptoge et al. 2010; de Ferranti and Rifai 2007). "
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    ABSTRACT: Blue-collar workers have an increased risk of cardiovascular disease. Accordingly, elevated levels of biomarkers related to risk of cardiovascular disease, such as high-sensitive C-reactive protein, have been observed among blue-collar workers. The objective was to examine whether an aerobic exercise worksite intervention changes the level of inflammation biomarkers among cleaners. The design was a cluster-randomized controlled trial with 4-month worksite intervention. Before the 116 cleaners aged 18-65 years were randomized, they signed an informed consent form. The reference group (n = 59) received lectures, and the aerobic exercise group (n = 57) performed worksite aerobic exercise (30 min twice a week). Levels of biomarkers (high-sensitive C-reactive protein, fibrinogen, cholesterol, low- and high-density lipoprotein cholesterol and triglyceride) were collected at baseline and after 4 months. A repeated-measure, multi-adjusted, mixed-model intention-to-treat analysis was applied to compare between-group differences. The study was registered as ISRCTN86682076. Significant (p < 0.05) between-group reductions from baseline to follow-up were found for high-sensitive C-reactive protein (-0.54 ± 0.20 µg/ml; 95 % CI -0.94, -0.14), low-density lipoprotein cholesterol (-0.32 ± 0.11 mmol/L; 95 % CI -0.54, -0.10) and the ratios of LDL/HDL (-0.30 ± 0.08; 95 % CI -0.46, -0.14), and LDL/TC cholesterol (-0.04 ± 0.02; 95 % CI -0.07, -0.01). This study indicates that an aerobic exercise intervention among cleaners leads to reduced levels of high-sensitive C-reactive protein and low-density lipoprotein cholesterol, and an unaltered level of fibrinogen. The aerobic exercise seems to improve inflammatory levels and lipoprotein profile among cleaners, with no signs of cardiovascular overload.
    No preview · Article · Jul 2015 · International Archives of Occupational and Environmental Health
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    • "The worksite presents extensive opportunities to reach large numbers of people for health promotion and disease prevention, given that most of the adult population is employed. We reviewed 10 randomized controlled trials (RCTs) of worksite physical activity interventions and found substantial heterogeneity between studies for effects on overweight outcomes (Harma et al., 1988; King et al., 1989; Oden et al., 1989; Gemson and Sloan, 1995; Grandjean et al., 1996; Lee and White, 1997; Pritchard et al., 1997; Fukahori et al., 1999; Proper et al., 2003; Elliot et al., 2004). A quality check of these studies revealed that such inconsistencies are likely owing to methodological shortcomings (most studies prescribed unspecified doses of unsupervised exercise) and/or inadequate weight loss programme design (most studies did not prescribe a dietary intervention), or participant characteristics affecting exercise adoption as well as treatment response (clinical heterogeneity). "
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    ABSTRACT: Overweight and physical inactivity are risk factors for increased disease burden and health care expenditure. Well-designed studies are still needed to determine the treatment efficacy of worksite interventions targeting such risk factors. This randomized controlled trial was conducted at one of Australia's casinos in 2002-2003, to investigate the effects of a comprehensive exercise and lifestyle intervention on physical fitness. Only 6.4% of the workforce expressed interest in being study participants. Seventy-three employees (aged 32 +/- 8 years, 51% overweight/obese, 73% shift workers and 52% women) were recruited and randomized to treatment or wait-list control groups for 24 weeks, 44 of whom completed the intervention. Components of the intervention include supervised moderate-to-high intensity exercise including combined aerobic (at least 20 min duration 3 days/week) and weight-training (for an estimated 30 min completed 2-3 days/week), and dietary/health education (delivered via group seminars, one-on-one counselling and literature through the provision of a worksite manual). ANCOVA, by intention-to-treat and of study completers, found significant between-group differences in the mean waist circumference and predicted maximal oxygen uptake (VO2max), favouring the intervention, but effects were concentrated in one subject. For study completers, between-group differences in the mean waist circumference (82.3 +/- 9.2 versus 90.5 +/- 17.8 cm, p = 0.01) and predicted VO2max (47 versus 41 ml/kg/min, p < 0.001) remained significant without the outlier, favouring the intervention. Higher intervention compliance predicted greater improvements in physical fitness. No significant effects on body mass or body mass index were found. This worksite intervention significantly improved waist circumference and aerobic fitness in healthy but sedentary employees, most of whom were shift workers. Worksite interventions have the potential to counter the increasing burden of overweight and obesity, particularly visceral adiposity, as well as physical inactivity; however, substantial barriers to adoption/adherence need to be overcome for greater feasibility and impact on employee physical health.
    Preview · Article · Sep 2006 · Health Promotion International
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    • "port the evidence that aerobic - type training exercise is effective in the improvement of blood lipid profile for both normolipidemic ( Dufaux et al . 1982 ) and hyperlipidemic individuals ( Superko and Haskell 1987 ) ; however , longitudinal studies are somewhat difficult to evaluate and do not demonstrate a clear influence on lipid metabolism ( Grandjean et al . 1996 ) . Moreover , there are disparate results concerning training peculiar - ities that could elicit changes on blood lipids , such as the type , the energy expenditure , the frequency , and the duration of each exercise session as well as the length of overall training period ( Durstine et al . 2001 ; Ferguson et al . 1998 ) . Recently , "
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    ABSTRACT: The aim of this study was to evaluate in sedentary individuals the effects of a 20-week exercise training program on ex vivo platelet responsiveness and the possible involvement of plasma antioxidant defences in relation to the mechanisms controlling platelet sensitivity. A statistically significant decrease in ADP- and collagen-evoked platelet aggregation was observed after physical training together with an increase in plasma total antioxidant capacity (TEAC), superoxide dismutase activity, and high-density lipoprotein cholesterol (HDL-C) concentration. Additionally, a rise in lag time for in vitro low-density lipoprotein (LDL) oxidation as well as a decreased plasma level of secondary products of lipid peroxidation were observed after training, and the values for lag time were significantly correlated with TEAC and HDL-C. Nitrate/nitrite (NOx) content both in plasma and in platelet cytosol was significantly enhanced at the end of the training period and a significant positive correlation was found between plasma and intraplatelet NOx values. Furthermore, intraplatelet NOx content was positively correlated with HDL-C levels. The findings of the current study suggest that the improvement of antioxidant defences induced by moderate regular exercise may be involved in desensitising blood platelets most likely through the inhibition of LDL oxidation and the simultaneous enhancement of plasma and intraplatelet NOx bioavailability and HDL-C level.
    Full-text · Article · May 2004 · Arbeitsphysiologie
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