I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction

Tularik, Inc., South San Francisco, CA 94080, USA.
Proceedings of the National Academy of Sciences (Impact Factor: 9.67). 09/1996; 93(16):8241-6. DOI: 10.1073/pnas.93.16.8241
Source: PubMed


Tumor necrosis factor (TNF) receptor-associated factor (TRAF) proteins associate with and transduce signals from TNF receptor 2, CD40, and presumably other members of the TNF receptor superfamily. TRAF2 is required for CD40- and TNF-mediated activation of the transcription factor NF-kappa B. Here we describe the isolation and characterization of a novel TRAF-interacting protein, I-TRAF, that binds to the conserved TRAF-C domain of the three known TRAFs. Overexpression of I-TRAF inhibits TRAF2-mediated NF-kappa B activation signaled by CD40 and both TNF receptors. Thus, I-TRAF appears as a natural regulator of TRAF function that may act by maintaining TRAFs in a latent state.

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