Article

Human plasma DSIP decreases at the initiation of sleep at different circadian times

Universität Basel, Bâle, Basel-City, Switzerland
Peptides (Impact Factor: 2.62). 02/1995; 16(8):1475-81. DOI: 10.1016/0196-9781(95)02027-6
Source: PubMed

ABSTRACT

Nocturnal plasma delta sleep-inducing peptide-like immunoreactivity (DSIP-LI) was determined serially in seven healthy male subjects. Time courses during nocturnal sleep (2300-0800 h), nocturnal sleep deprivation (2300-0500 h), and morning recovery sleep (0500-0800 h) after sleep deprivation were compared. A significant decrease in plasma DSIP-LI was found at the transition from wakefulness to sleep in both evening sleep (2300 h) and morning recovery sleep (0500 h). Time courses were accompanied by physiological changes in sleep electroencephalographic slow-wave activity, and in plasma concentrations of cortisol and human growth hormone. No sleep stage specificity was found. It is concluded that DSIP is influenced by the initiation of sleep.

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    • "A close correlation between the diurnal rhythm of DSIP-LI and that of body temperature was detected. It was concluded that endogenous elevation of DSIP may be associated with suppression of both SWS and paradoxical sleep (PS), and that the circadian rhythm of DSIP is coupled directly or indirectly to that of body temperature (Friedman et al. 1994b; Schulz et al. 1994; Seifritz et al. 1995; Steiger and Holsboer 1997); (iv) cardiotropic and vasomotor activity (DSIP can normalize blood pressure and myocardial contraction; Schoenenberger 1984; Yehuda et al. 1988; Inoué 1989; Prudchenko et al. 1994; Strekalova 1998); (v) pain, where DSIP can produce an analgesic effect by augmenting met-encephalin binding with opiate receptors (Schoenenberger 1984; Yehuda et al. 1988; Inoué et al. 1990; Prudchenko et al. 1994; Lysenko et al. 1995; Strekalova 1998; Pollard and Pomfrett 2001); (vi) regulation of diurnal and circadian rhythmicity (Friedman et al. 1994b; Schulz et al. 1994; Seifritz et al. 1995 ; Vgontzas et al. 1995) ; ( vii) anti - opioid and anti - alcohol activity ( DSIP can suppress the development of alcohol and opiate dependency this being the basis for DSIP clinical application ; Yukhana - nov et al. 1991 , 1992 ; Soyka and Rothenhaeusler 1997 ; Backmund et al . 1998 ; Hruz et al . "
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