Article

Vincent JL, Moreno R, Takala J, et al. The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. Intensive Care Med. 22: 707

Erasme University Hospital, Brussels, Belgium.
Intensive Care Medicine (Impact Factor: 7.21). 08/1996; 22(7):707-10. DOI: 10.1007/BF01709751
Source: PubMed
Download full-text

Full-text

Available from: Rui Moreno, May 09, 2014
  • Source
    • "Most data will be extracted from ongoing documentations and patients' health records, some data will have to be specifically assessed for the purpose of the study.[23]General medical characteristics height, weight, waist circumference history of smoking, current smoking comorbidity according to SAPS III[32]history of psychiatric disorders Medical characteristics relating to ARDS and its treatment cause and severity of ARDS according to the " Berlin- Definition "[15]prognostic scores at ICU admission SAPS II[31], SAPS III[32]organ dysfunction/failure SOFA[33]blood gas analysis ventilation parameters presence of delirium CAM-ICU, RASS[41]treatment with supportive care measures: ECMO, NO-inhalation, prone-positioning, muscle relaxant medication, tracheotomy complications length of ICU stay Characteristics of health institution use length of hospital stay before referral to specialized centre, duration of inter-hospital transport, length and type of rehabilitative measures outpatient health-service use Psycho-social characteristics prevalence of psychopathological syndromes: major depressive syndrome, panic syndrome, PTSD, alcohol abuse PHQ[26], PTSS-14[28,29]disability Barthel-Index of Activities of Daily Living[42,43]social support F-SOZU[30]healthrelated quality of life SF-12[21]return to work "
    [Show abstract] [Hide abstract]
    ABSTRACT: Background: Health-related quality of life (HRQoL) and return to work are important outcomes in critical care medicine, reaching beyond mortality. Little is known on factors predictive of HRQoL and return to work in critical illness, including the acute respiratory distress syndrome (ARDS), and no evidence exists on the role of quality of care (QoC) for outcomes in survivors of ARDS. It is the aim of the DACAPO study ("Surviving ARDS: the influence of QoC and individual patient characteristics on quality of life") to investigate the role of QoC and individual patient characteristics on quality of life and return to work. Methods/Design: A prospective, observational, multi-centre patient cohort study will be performed in Germany, using hospitals from the "ARDS Network Germany" as the main recruiting centres. It is envisaged to recruit 2400 patients into the DACAPO study and to analyse a study population of 1500 survivors. They will be followed up until 12 months after discharge from hospital. QoC will be assessed as process quality, structural quality and volume at the institutional level. The main outcomes (HRQoL and return to work) will be assessed by self-report questionnaires. Further data collection includes general medical and ARDS-related characteristics of patients as well as sociodemographic and psycho-social parameters. Multilevel hierarchical modelling will be performed to analyse the effects of QoC and individual patient characteristics on outcomes, taking the cluster structure of the data into account. Discussion: By obtaining comprehensive data at patient and hospital level using a prospective multi-centre design, the DACAPO-study is the first study investigating the influence of QoC on individual outcomes of ARDS survivors.
    Full-text · Article · Dec 2015 · BMC Health Services Research
  • Source
    • "To evaluate the severity of acute pancreatitis, C-reactive protein (CRP) [2], number of patients with Blood Urea Nitrogen (BUN) !20 mg/dl [30], Acute Physiology and Chronic Health Evaluation II (APACHE II) score [31] [32], Systemic Inflammatory Response Syndrome (SIRS) score [33], Sequential Organ Failure Assessment (SOFA) score [34], and Japanese severity score [35] "
    [Show abstract] [Hide abstract]
    ABSTRACT: To investigate the efficacy of recombinant human soluble thrombomodulin (rTM) in preventing the development of walled-off necrosis (WON) in severe acute pancreatitis (SAP) patients. We retrospectively analyzed 54 SAP patients divided into two groups: SAP patients treated by rTM (rTM group, 24 patients) and not treated by rTM (control group, 30 patients). rTM was administered to patients with disseminated intravascular coagulation (DIC). Initially, on the admission day, we recorded patient severity and pancreatic necrosis/ischemia positive or negative. Then we investigated development of WON using 4 weeks later CT/MRI. Finally we compared the proportions of patients developing WON in the rTM group and the control group. On the admission day, the condition of patients treated by rTM was significantly worse than patients in the control group; rTM group vs. 71.8 ± 13.9 vs. 59.8 ± 15.3 years for age, 10.7 ± 3.5 vs. 8.0 ± 4.4 for Acute Physiology and Chronic Health Evaluation II (APACHE II) score, and 3.3 ± 1.8 vs. 2.2 ± 1.8 for sequential organ failure assessment (SOFA) score (p < 0.05). We found no significant differences on the admission day in rate of pancreatic necrosis/ischemia between patients treated by rTM and controls (58.3% vs. 63.3%, p = 0.71). Nevertheless, the proportion of patients developing WON was significantly lower among those administered rTM than in those not administered rTM {29.2% (7/24 patients) vs. 56.7% (17/30 patients), p < 0.05}. Treatment of SAP patients treated by rTM may prevent progression from pancreatic necrosis/ischemia to WON. Copyright © 2015 IAP and EPC. Published by Elsevier B.V. All rights reserved.
    Full-text · Article · Aug 2015 · Pancreatology
  • Source
    • "The expected mortality rate (EMR) is calculated from the SAPS3. The Sequential Organ Failure Assessment (SOFA) score was developed to better describe the progression of organ failure with a simple scoring system [14] and is calculated daily. The SOFA is used to estimate the degree of organ dysfunction. "
    [Show abstract] [Hide abstract]
    ABSTRACT: The purposes of the study are to compare point-of-care (POC) hemostatic devices in critically ill patients with routine laboratory tests and intensive care unit (ICU) outcome scoring assessments and to describe the time course of these variables in relation to mortality rate. Patients admitted to the ICU with a prognosis of more than 3 days of stay were included. The POC devices, Multiplate platelet aggregometry, rotational thromboelastometry, and ReoRox viscoelastic tests, were used. All variables were compared between survivors and nonsurvivors. Point-of-care results were compared to prothrombin time, activated partial thromboplastin time, platelet count, fibrinogen concentration, and Sequential Organ Failure Assessment score and Simplified Acute Physiology Score 3. Blood was sampled on days 0 to 1, 2 to 3, and 4 to 10 from 114 patients with mixed diagnoses during 237 sampling events. Nonsurvivors showed POC and laboratory signs of hypocoagulation and decreased fibrinolysis over time compared to survivors. ReoRox detected differences between survivors and nonsurvivors better than ROTEM and Multiplate. All POC and routine laboratory tests showed a hypocoagulative response in nonsurvivors compared to survivors. ReoRox was better than ROTEM and Multiplate at detecting differences between surviving and nonsurviving ICU patients. However, Simplified Acute Physiology Score 3 showed the best association to mortality outcome. Copyright © 2015. Published by Elsevier Inc.
    Full-text · Article · Jun 2015 · Journal of critical care
Show more