Neutralization serotypes of human immunodeficiency virus type 1 field isolates are not predicted by genetic subtype. The WHO Network for HIV Isolation and Characterization

Department of Communicable Diseases, Imperial College School of Medicine at St. Mary's, London, United Kingdom.
Journal of Virology (Impact Factor: 4.44). 12/1996; 70(11):7827-32.
Source: PubMed


Human immunodeficiency virus type 1 (HIV-1) primary isolates from four geographical locations in Thailand, Brazil, Rwanda, and Uganda, representing genetic subtypes A, B, C, D, and E, were examined for autologous and heterologous neutralization by panels of human HIV+ polyclonal plasma. In independent linked experiments in three laboratories using diverse methodologies and common reagents, no defined pattern of genetic subtype-specific neutralization was observed. Most plasma tested were broadly cross-neutralizing across two or more genetic subtypes, although the titer of neutralization varied across a wide range. We conclude that the genetic subtypes of HIV-1 are not classical neutralization serotypes.

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Available from: Eva-Maria Fenyo, Oct 03, 2014
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    • "It is intriguing to note that while superinfection by discordant HIV-1 subtypes helps to boost the humoral immune response against heterologous viruses [38], it does not boost the response against its early autologous viruses. Previous studies have demonstrated that different HIV-1 subtype strains share conserved antigenic epitopes while also harboring epitopes that are unique to them [41]–[51]. Therefore, the possibility exists that distinct antigenic epitopes from the discordant HIV-1 subtypes infecting these patients broaden the immune response to different viruses. "
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    • "Subtype C circulates mainly in Southern and East Africa, South and South East Asia, and Southern Brazil, and two CRFs with largely subtype C genomes, 08_BC and 07_BC, are the major HIV-1 clades circulating in China. Most initial studies failed to find correlations of HIV-1 subtypes with susceptibility to neutralizing antibody responses (Kostrikis et al., 1996; Moore et al., 1996; Nyambi et al., 1996; Weber et al., 1996), with the exception of the CRF01_AE variant circulating in South East Asia, which correlates to a neutralization serotype (Kostrikis et al., 1996; Mascola et al., 1994; Mascola et al., 1996). However, subsequent studies have found some correlations between HIV-1 subtypes and susceptibility to neutralizing antibody (Binley et al., 2004; Blish et al., 2009; Brown et al., 2008; Li et al., 2006; Seaman et al., 2010; Simek et al. 2009; van Gils et al., 2010) and T-cell responses (Cao et al., 2000; Coplan et al., 2005; Currier et al., 2003; Geldmacher et al., 2007; McKinnon et al., 2005), with the detection of preferential intraclade reactivities. "
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