Prodynorphin mRNA expression in the rat dentate gyrus after cerebral ischemia

ArticleinNeuropeptides 30(4):355-8 · September 1996with4 Reads
Impact Factor: 2.64 · DOI: 10.1016/S0143-4179(96)90024-4 · Source: PubMed


    The beneficial effects of exogenous kappa receptor agonists in preventing neuronal damage elicited by brain ischemia suggest a role for endogenous dynorphins. In agreement prodynorphin (PDYN) gene expression in granule cells of the dentate gyrus detected by in situ hybridization was drastically but transiently decreased 18-32 h after four-vessel cerebral ischemia for 20 min in rats. We propose that decreased dynorphin synthesis and release could contribute to the delayed neuronal death of hippocampal pyramidal cells in this model.