Meat intake, heterocyclic amines, and risk of breast cancer: A case- control study in Uruguay

Registro Nacional de Cancer, Department 402, Montevideo, Uruguay.
Cancer Epidemiology Biomarkers & Prevention (Impact Factor: 4.13). 09/1997; 6(8):573-81.
Source: PubMed


To study the effects of meat intake, including heterocyclic amine exposure, on the risk of breast cancer, we conducted a hospital-based case-control study involving 352 patients with breast cancer and 382 controls. A strong effect of red meat, total meat, beef, fried meat, and heterocyclic amine exposure was found, after controlling for potential confounders. The odds ratio for the highest quartile of 2-amino-3-methylimidazo [4,5-f]quinoline exposure was 3.34 (95% confidence interval 1.85-6.02). According to these results, meat intake and chemicals formed during the cooking process appear to be strong risk factors in human breast carcinogenesis.

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    • "In other words, a developing country has shown a high occurrence of a disease which is typical of developed countries. We and others have thoroughly studied possible links of nutrition and BC, from the dietary viewpoint (Ronco et al., 1996; 1999; 2002; 2003; 2006; 2010a,b,c,d; De Stéfani et al., 1997a,b; 1998) as well as from an anthropometric one (Ronco et al., 2008; 2009) and other epidemiologic ones (Ronco et al., 2007; 2009). In order to explore the associations among anthropometry (BMI, body "
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    ABSTRACT: Obese postmenopausal women increase their risk of developing breast cancer (BC), in particular if they display an android-type pattern of adiposity, which is also associated to increased risks of diabetes mellitus, hypertension and cardiovascular disease. In order to explore the associations among anthropometry (body mass index, body composition, somatotype), some specific items of medical history (diabetes, hypertension, dislypidemias, hyperuricemia) and the risk of BC in Uruguayan women, a case-control study was carried out between 2004-2009 at our Oncology Unit. 912 women of ages between 23-69 years (367 new BC cases and 545 non hospitalized, age-matched controls with a normal mammography) were interviewed. Twenty body measurements were taken in order to calculate body composition and somatotype. Patients were queried on socio-demographics, reproductive history, family history of cancer, a brief food frequency questionnaire and on personal history of diabetes, dislypidemias, hyperuricemia, hypertension and gallbladder stones. Uni- and multivariate analyses were done, generating odds ratios (ORs) as an expression of relative risks. A personal history of diabetes was positively associated to BC risk (OR=1.64, 95% CI 1.00-2.69), being higher among postmenopausal women (OR=1.92, 95% CI 1.04-3.52). The risks of BC for diabetes in postmenopausal women with overweight combined with dislypidemia (OR=9.33, 95% CI 2.10-41.5) and high fat/muscle ratio (OR=7.81, 95% CI 2.01-30.3) were significantly high. As a conclusion, a personal history of diabetes and overweight was strongly associated to BC. The studied sample had a subset of high-risk of BC featured by postmenopausal overweight and diabetic women, who also had a personal history of hypertension and/or dyslipidemia. The present results could contribute to define new high risk groups and individuals for primary as well as for secondary prevention, since this pattern linked to the metabolic syndrome is usually not considered for BC prevention.
    Preview · Article · Jan 2012 · Asian Pacific journal of cancer prevention: APJCP
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    • "vegetariansthanamongmeateaters.Nitrosamines,which areknownasbladdercarcinogensortheirprecursors,are foundincertainmeatitems(Scanlan,1983;Dichetal.,1996). Apositiveassociationwithbladdercancerwasdetectedina cohortforintakeofchickenwithoutskin,butnotforchicken withskinorothermeats,includingprocessedmeats(Michaudetal .,2006).Mostcase–controlstudiestodatehave reportednoassociationsformeatintakeandbladdercancer (LaVecchiaandNegri,1996;Steinmausetal.,2000).Red meathasalsobeenimplicatedincolonandrectalcancer (Donaldson,2004).Meatandtheheterocyclicaminesformed incookinghavebeencorrelatedtobreastcancerinacase– controlstudyinUruguayaswell(DeStefanietal.,1997). Whenstratifiedaccordingtostages,thedifferencebetweentheAAandAC+CC(dominantmodel )genotype frequencieswasmorepronouncedincaseofmuscle-invasive (4.39-fold)ratherthaninsuperficial(1.55-fold)bladdercan- "
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    ABSTRACT: For the present study, two polymorphisms, xeroderma pigmentosum, complementation group D (XPD) Lys751Gln and RAD51 135G/C were studied with regard to bladder cancer. For XPD Lys751Gln polymorphism, an increased risk of bladder cancer was found to be associated with the Gln variant allele (odds ratio [OR]=1.86, 95% confidence interval [CI]=1.27-2.73), on taking AA (Lys/Lys) as the referent genotype. In males, the XPD 751C (Gln) allele was found to be associated with a significantly increased risk (OR=2.33, 95% CI=1.52-3.56). The inhabitants of rural areas showed a significantly increased risk with the XPD Gln allele (OR=2.59, 95% CI=1.46-4.62) when compared with those of urban areas. In smokers (OR=5.30, 95% CI=2.42-11.68), alcohol drinkers (OR=4.33, 95% CI=2.17-8.70), and nonvegetarians (OR=2.21, 95% CI=1.26-3.87), the XPD Gln allele showed a significantly increased risk toward bladder cancer. For RAD51 135G/C polymorphism, no significant difference was observed in the allelic and genotypic frequencies. Even after stratification, no significant association could be seen. After stratifying histopathologically, the RAD51 CC genotype was associted with decreased risk in subjects having superficial stage (OR=0.51, 95% CI=0.27-0.99) and with those having G2 grade (OR=0.24, 95% CI=0.09-0.62) of bladder cancer. XPD polymorphism may be a predisposing factor, but the same cannot be said for RAD51 gene polymorphism.
    Full-text · Article · Jul 2011 · DNA and cell biology
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    • "The protective effect of the total dietary fiber intake on breast cancer risk is in agreement with previous epidemiological studies. Seven case–control studies published recently (Graham et al., 1991; Baghurst and Rohan, 1994; Yuan et al., 1995; Freudenheim et al., 1996; De Stefani et al., 1997b; Ronco et al., 1999; Shaham et al., 2006) and six prospective cohort studies (Rohan et al., 1993; Holmes et al., 2004; Mattisson et al., 2004; Cade et al., 2007; Suzuki et al., 2008; Park et al., 2009) have suggested an inverse association between dietary fiber intake and breast cancer risk. "
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    ABSTRACT: There is few data on the association between dietary fiber intake and estrogen receptor (ER)/progesterone receptor (PR)-defined breast cancer risk. The present study aimed to investigate the associations between total dietary fiber and dietary fiber fractions intake and breast cancer risk by ER and PR status in a hospital-based case-control study among Chinese women. Four hundred and thirty-eight cases with primary breast cancer were consecutively recruited from June 2007 to August 2008 and frequency matched to 438 controls by age (5-year interval) and residence (rural/urban). A validated food frequency questionnaire was used to assess the dietary intake through a face-to-face interview. Unconditional logistic regression models were used to estimate odds ratios (ORs) and 95% confidence interval (CI) after adjusting for various potential confounders. A statistically significant inverse association was found between total dietary fiber and fiber fractions intake and breast cancer risk. The adjusted ORs (95% CIs) for the highest versus the lowest quartile of intake were 0.31 (0.20-0.47) for total dietary fiber, 0.73 (0.48-1.11) for soy fiber, 0.48 (0.22-0.97) for vegetable fiber and 0.54 (0.31-0.92) for fruit fiber. No association was observed for cereal fiber intake and risk. An inverse association between dietary fiber intake and breast cancer risk was observed in ER+, ER-, PR+, ER+PR+ and ER-PR+ tumors. Our results suggest that consumption of total dietary fiber and fiber from vegetable and fruit was inversely associated with breast cancer risk. These inverse associations were more prominent in some subtypes of ER and PR breast cancers.
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