Psychiatric Symptoms in a Patient with Diabetes Mellitus Associated with Point Mutation in Mitochondrial DNA

ArticleinBiological Psychiatry 42(11):1067-9 · January 1998with1 Read
Impact Factor: 10.26 · DOI: 10.1016/S0006-3223(97)00351-X · Source: PubMed
    • "However, the deletions, insertions, modifications, and other rearrangements described in these studies represent damage done to mtDNA in the liver, white blood cells, and elsewhere as a consequence of oxidative stress associated with chronic ethanol consumption [1,2] . Only a small number of studies have detected associations between mtDNA polymorphisms and psychiatric disorders and syndromes that overlap those of chronic alcoholism [3,4] . These observations , plus the possibility that heritable mtDNA mutations could influence susceptibility to alcohol-induced oxidative stress damage, motivate our current study in which we analyze data from the Collaborative Study of the Genetics of Alcoholism (COGA) [5] to detect and characterize mitochondrial genetic effects on variation in latent class psychiatric/behavioral variables. "
    [Show abstract] [Hide abstract] ABSTRACT: We report the results of statistical genetic analyses of data from the Collaborative Study on the Genetics of Alcoholism prepared for the Genetic Analysis Workshop 14 to detect and characterize maternally inherited mitochondrial genetic effects on variation in latent class psychiatric/behavioral variables employed in the diagnosis of alcoholism. Using published extensions to variance decomposition methods for statistical genetic analysis of continuous and discrete traits we: 1) estimated the proportion of the variance in each trait due to the effects of mitochondrial DNA (mtDNA), 2) tested for pleiotropy, both mitochondrial genetic and residual additive genetic, between trait pairs, and 3) evaluated whether the simultaneous estimation of mitochondrial genetic effects on these traits improves our ability to detect and localize quantitative trait loci (QTL) in the nuclear genome. After correction for multiple testing, we find significant (p < 0.009) mitochondrial genetic contributions to the variance for two latent class variables. Although we do detect significant residual additive genetic correlations between the two traits, there is no evidence of a residual mitochondrial genetic correlation between them. Evidence for autosomal QTL for these traits is improved when linkage screens are conditioned on significant mitochondrial genetic effects. We conclude that mitochondrial genes may contribute to variation in some latent class psychiatric/behavioral variables associated with alcoholism.
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