Article

Serotonin transporter and seasonal variation in blood serotonin in families with obsessive-compulsive disorder

Department of Pediatrics, University of Chicago, Chicago, Illinois, United States
Neuropsychopharmacology (Impact Factor: 7.05). 03/1998; 18(2):102-11. DOI: 10.1016/S0893-133X(97)00097-3
Source: PubMed

ABSTRACT

The serotonin transporter (HTT) is a candidate gene for obsessive-compulsive disorder (OCD) that has been associated with anxiety-related traits. The long (l) and short (s) variants of the HTT promoter have different transcriptional efficiencies. HTT promoter genotype and blood 5-HT concentration were examined in 70 subjects from 20 families ascertained through children and adolescents with a DSM-III-R diagnosis of OCD. The HTT promoter variant had a significant effect on blood 5-HT content. Subjects with the l/l and l/s genotypes had significantly higher blood 5-HT levels than did those with the s/s genotype. There was a significant interaction between HTT promoter genotype and seasonal variation in blood 5-HT content, with significant seasonal differences in 5-HT occurring only in the subjects with the l/l genotype. Further studies of the regulation of HTT gene expression are indicated.

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Available from: Gregory L Hanna, May 14, 2014
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    • "Heils et al. (1995, 1996) first reported the 5-HTT promoter region polymorphism identified at the promoter site of approximately 1 kb and demonstrated that the polymorphism could alter transcriptional levels of 5-HTT whilst, Collier et al. (1996) reported that the polymorphism (44 bp insertion and deletion) affected the expression efficiency of 5-HT, and proposed that it was linked to various mental disorders. The short (s) and long (l) allele variants of 5-HTT functional length promoter polymorphic region are called 5-HTTLPR and it has been shown that subjects with s allele (s/s or s/l) have lower 5-HT levels in blood platelets, lymphoblast cell and brain (Hanna et al., 1998; Lesch et al., 1996; Little et al., 1998). These studies prompted several research groups to investigate the role of 5-HTTLPR in depression and other neuroticism, of which some of the studies showed 5-HTTLPR association with anxiety, agreeableness, other neuroticism (Lesch et al., 1996, Greenberg et al., 2000, Melke et al., 2001), anticipatory worry and fear of uncertainity (Mazzanti et al., 1998) while others did not (Gustavsson et al., 1999; Jorm et al., 1998). "
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    • "Subjects with the l/l and l/s genotypes had significantly higher blood 5-hydroxytryptamine (5-HT) levels than those with the s/s genotype. There was a significant interaction between HTT promoter genotype and seasonal variation in blood 5-HT content, with significant seasonal differences in 5-HT occurring only in the subjects with the l/l genotype[21]. Yoney et al.[22]found that the patients with OCD did not report a greater degree of seasonal variations than normal and no response was seen to bright light therapy in the small number of patients treated. On the other hand, Höflich et al.[23]reported the case of a 40-year-old woman with a seasonal form of OCD which was usually accompanied by obsessions and occurred only in autumn or winter. "
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