Rizzuto, C.D. et al. A conserved HIV gp120 glycoprotein structure involved in chemokine receptor binding. Science 280, 1949-1953

ArticleinScience 280(5371):1949-53 · July 1998with17 Reads
Impact Factor: 33.61 · DOI: 10.1126/science.280.5371.1949 · Source: PubMed


    The entry of primate immunodeficiency viruses into target cells depends on a sequential interaction of the gp120 envelope
    glycoprotein with the cellular receptors, CD4 and members of the chemokine receptor family. The gp120 third variable (V3)
    loop has been implicated in chemokine receptor binding, but the use of the CCR5 chemokine receptor by diverse primate immunodeficiency
    viruses suggests the involvement of an additional, conserved gp120 element. Through the use of gp120 mutants, a highly conserved
    gp120 structure was shown to be critical for CCR5 binding. This structure is located adjacent to the V3 loop and contains
    neutralization epitopes induced by CD4 binding. This conserved element may be a useful target for pharmacologic or prophylactic
    intervention in human immunodeficiency virus (HIV) infections.