Weight loss in obese infertile women results in improvement in reproductive outcome for all forms of fertility treatment

University of Adelaide, Tarndarnya, South Australia, Australia
Human Reproduction (Impact Factor: 4.57). 07/1998; 13(6):1502-5. DOI: 10.1093/humrep/13.6.1502
Source: PubMed


Obesity affects ovulation, response to fertility treatment, pregnancy rates and outcome. In this prospective study, a weight
loss programme was assessed to determine whether it could help obese infertile women, irrespective of their infertility diagnosis,
to achieve a viable pregnancy, ideally without further medical intervention. The subjects underwent a weekly programme aimed
at lifestyle changes in relation to exercise and diet for 6 months; those that did not complete the 6 months were treated
as a comparison group. Women in the study lost an average of 10.2 kg/m2, with 60 of the 67 anovulatory subjects resuming spontaneous
ovulation, 52 achieving a pregnancy (18 spontaneously) and 45 a live birth. The miscarriage rate was 18%, compared to 75%
for the same women prior to the programme. Psychometric measurements also improved. None of these changes occurred in the
comparison group. The cost savings of the programme were considerable. Prior to the programme, the 67 women had had treatment
costing a total of A$550,000 for two live births, a cost of A$275,000 per baby. After the programme, the same women had treatment
costing a total of A$210,000 for 45 babies, a cost of A$4600 per baby. Thus weight loss should be considered as a first option
for women who are infertile and overweight.

  • Source
    • "Regular cycling activity generates physical and mental benefits, such as losing weight, reducing stress and improving fitness (Clark et al., 1998). An increase in the number of cyclists can reduce car dependence, demand for parking spaces, energy consumption, road congestion and traffic related air-pollution. "
    [Show abstract] [Hide abstract]
    ABSTRACT: The objective of this study is to understand the relationship between built environment factors and bicycle crashes with motor vehicles involved in Seattle. The research method employed is a Poisson lognormal random effects model using hierarchal Bayesian estimation. The Traffic Analysis Zone (TAZ) is selected as the unit of analysis to quantify the built environment factors. The assembled dataset provides a rich source of variables, including road network, street elements, traffic controls, travel demand, land use, and socio-demographics. The research questions are twofold: how are the built environment factors associated with the bicycle crashes, and are the TAZ-based bicycle crashes spatially correlated? The findings of this study are: (1) safety improvements should focus on places with more mixed land use; (2) off-arterial bicycle routes are safer than on-arterial bicycle routes; (3) TAZ-based bicycle crashes are spatially correlated; (4) TAZs with more road signals and street parking signs are likely to have more bicycle crashes; and (5) TAZs with more automobile trips have more bicycle crashes. For policy implications, the results suggest that the local authorities should lower the driving speed limits, regulate cycling and driving behaviors in areas with mixed land use, and separate bike lanes from road traffic.
    Full-text · Article · Nov 2015 · Safety Science
  • Source
    • "Physical activity has a protective effect on fertility along with weight loss. In infertile obese women who experienced weight loss (about 10 kg/m 2 ) through diet and exercise intervention, resumed spontaneous ovulation , achieved spontaneous pregnancy, had lower miscarriage rates, and increased live birth [66] . Obese, infertile women (BMI > 30) who previously could not achieve conception and were engaged in a diet and exercise regime for at least 6 months (reduction in BMI of about 9.6) had improved spontaneous conception rate and with ovulation induction therapy had improved pregnancy outcome [67] . "
    [Show abstract] [Hide abstract]
    ABSTRACT: Human fertility is influenced by multiple factors, some more strongly than others. While not all factors are under our control, certainly most lifestyle factors are amenable to change to some extent, in order to minimize its adverse effects on fertility. Factors, such as couple's age during conception, body weight, smoking tobacco, alcohol and caffeine consumption, diet and exercise, use of illicit drugs, and sexually transmitted infections, can influence the couple's fertility potential. Adopting a healthier lifestyle contributes toward optimal fertility, which will enhance natural conception, promote a safer pregnancy leading to the live birth of a healthy baby. This chapter reviews studies on these individual lifestyle factors and discusses their findings. Knowledge on how these factors can impair fertility is essential to create awareness among couples who are planning to start a family or those who are already pregnant, in order to maximize their natural fertility potential and outcome.
    Full-text · Chapter · Apr 2015
  • Source
    • "Physical activity has been shown to confer a protective effect on fertility when coupled with weight loss in obese women [46]. However, excessive exercise can negatively alter energy balance in the body and affect the reproductive system [56]. "
    [Show abstract] [Hide abstract]
    ABSTRACT: Approximately 10 to 15% of couples are impacted by infertility. Recently, the pivotal role that lifestyle factors play in the development of infertility has generated a considerable amount of interest. Lifestyle factors are the modifiable habits and ways of life that can greatly influence overall health and well-being, including fertility. Many lifestyle factors such as the age at which to start a family, nutrition, weight, exercise, psychological stress, environmental and occupational exposures, and others can have substantial effects on fertility; lifestyle factors such as cigarette smoking, illicit drug use, and alcohol and caffeine consumption can negatively influence fertility while others such as preventative care may be beneficial. The present literature review encompasses multiple lifestyle factors and places infertility in context for the couple by focusing on both males and females; it aims to identify the roles that lifestyle factors play in determining reproductive status. The growing interest and amount of research in this field have made it evident that lifestyle factors have a significant impact on fertility.
    Full-text · Article · Jul 2013 · Reproductive Biology and Endocrinology
Show more