A fetal systemic inflammatory response is followed by the spontaneous onset of preterm parturition. Am J Obstet Gynecol

ArticleinAmerican Journal of Obstetrics and Gynecology 179(1):186-93 · August 1998with24 Reads
Impact Factor: 4.70 · DOI: 10.1016/S0002-9378(98)70271-6 · Source: PubMed


    OBJECTIVE: There is no evidence for the participation of the human fetus in the mechanisms responsible for the onset of preterm labor. We propose that preterm labor in the setting of infection results from the actions of proinflammatory cytokines secreted as part of the fetal and/or maternal host response to microbial invasion. The objective of this study was to determine whether a systemic fetal inflammatory response, defined as an elevation of fetal plasma interleukin-6 concentrations, has a temporal relationship with the commencement of labor.