Production of leukemia inhibitory factor (LIF) by T cells associates with type 2T helper (Th2) cytokines. Defective production of both by decidual T cells in unexplained recurrent abortions
Institute of Internal Medicine and Immunoallergology, University of Florence, Italy.Nature Medicine (Impact Factor: 27.36). 10/1998; 4(9):1020-4. DOI: 10.1038/2006
Leukemia inhibitory factor is essential for embryo implantation, and a shift from type 1 T-helper to type 2 T-helper response at the fetal-maternal interface may contribute to successful pregnancy. We show that LIF production is associated with type 2 T-helper cells, is upregulated by IL-4 and progesterone and is downregulated by IL-12, IFN-gamma and IFN-alpha. We also show a decreased production of LIF, IL-4 and IL-10 by decidual T cells of women with unexplained recurrent abortions in comparison with that of women with normal gestation. The defective production of LIF and/or type 2 T-helper cytokines may contribute to the development of unexplained recurrent abortions.