Free D- and L-amino acids in ventricular cerebrospinal fluid from Alzheimer and normal subjects

ArticleinAmino Acids 15(3):263-9 · September 1998with6 Reads
Impact Factor: 3.29 · DOI: 10.1007/BF01318865 · Source: PubMed

    Abstract

    Free D-Ser, D-Asp and total D-amino acids were significantly higher (p < 0.05) in Alzheimer (AD) ventricular CSF than in normal CSF. There was no significant difference in the total L-amino acids between AD and normal CSF, but L-Gln and L-His were significantly higher (p < 0.05) in AD-CSF. The higher concentrations of these D- and L-amino acids in AD ventricular CSF could reflect the degenerative process that occurs in Alzheimer's brain since ventricular CSF is the repository of amino acids from the brain.