Bacitracin Versus Mupirocin for Staphylococcus aureus Nasal Colonization •

ArticleinInfection Control and Hospital Epidemiology 20(5):351-3 · June 1999with20 Reads
Impact Factor: 4.18 · DOI: 10.1086/501633 · Source: PubMed


    We performed a randomized prospective study of 5-day treatment with topical mupirocin or bacitracin for the elimination of Staphylococcus aureus nasal colonization in healthcare workers (HCWs). Nasal cultures were obtained from 141 HCWs, 37 (26%) of whom showed S. aureus. After 72 to 96 hours of treatment, the organism was eradicated in 15 (94%) of 16 by mupirocin and in 8 (44%) of 18 by bacitracin (P = .0031). Similar efficacy was demonstrated at 30 days. Mupirocin may be more effective than bacitracin for eradication of S. aureus in healthy HCWs.