Antibacterial activity of honey against strains of Staphylococcus aureus from infected wounds. J R Soc Med

Department of Biological Sciences, The University of Waikato, Hamilton City, Waikato, New Zealand
Journal of the Royal Society of Medicine (Impact Factor: 2.12). 07/1999; 92(6):283-5.
Source: PubMed


The antibacterial action of honey in infected wounds does not depend wholly on its high osmolarity. We tested the sensitivity of 58 strains of coagulase-positive Staphylococcus aureus, isolated from infected wounds, to a pasture honey and a manuka honey. There was little variation between the isolates in their sensitivity to honey: minimum inhibitory concentrations were all between 2 and 3% (v/v) for the manuka honey and between 3 and 4% for the pasture honey. Thus, these honeys would prevent growth of S. aureus if diluted by body fluids a further seven-fold to fourteen-fold beyond the point where their osmolarity ceased to be completely inhibitory. The antibacterial action of the pasture honey relied on release of hydrogen peroxide, which in vivo might be reduced by catalase activity in tissues or blood. The action of manuka honey stems partly from a phytochemical component, so this type of honey might be more effective in vivo. Comparative clinical trials with standardized honeys are needed.

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    • "The antioxidants found in honey work on wounds through two means. First, the antioxidants fight against microorganisms and decrease infections at the site of the wound [60] [61] [62]. Second, the antioxidants reduce reactive oxygen species (ROS) and inflammations caused by the wound and aid in the healing process [62] [63] [64] [65]. "
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    ABSTRACT: Diabetic wounds are unlike typical wounds in that they are slower to heal, making treatment with conventional topical medications an uphill process. Among several different alternative therapies, honey is an effective choice because it provides comparatively rapid wound healing. Although honey has been used as an alternative medicine for wound healing since ancient times, the application of honey to diabetic wounds has only recently been revived. Because honey has some unique natural features as a wound healer, it works even more effectively on diabetic wounds than on normal wounds. In addition, honey is known as an "all in one" remedy for diabetic wound healing because it can combat many microorganisms that are involved in the wound process and because it possesses antioxidant activity and controls inflammation. In this review, the potential role of honey's antibacterial activity on diabetic wound-related microorganisms and honey's clinical effectiveness in treating diabetic wounds based on the most recent studies is described. Additionally, ways in which honey can be used as a safer, faster, and effective healing agent for diabetic wounds in comparison with other synthetic medications in terms of microbial resistance and treatment costs are also described to support its traditional claims.
    Full-text · Article · Oct 2014 · Evidence-based Complementary and Alternative Medicine
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    • "Honey, a best blend of sugars, is known since ancient time for its topical antimicrobial activity and has been used to treat ulcers and wounds (Molan 1992; Cooper et al., 1999). At first osmolarity of honey was thought to exert lethal effect on microbes but antimicrobial action of honey even after decimal dilution ward off the hypothesis (Cooper et al., 1999). Thereafter, release of hydrogen peroxide from honey was thought to be important reason behind the antimicrobial activity but that too is too low to cause the death of microbes (Molan, 1992). "
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    ABSTRACT: In the study antimicrobial activity of adonitol, arabinose, cellobiose, dulcitol, galactose, glycerol, glucose, inositol, lactose, maltose, mannitol, mannose, mellibiose, raffinose, salicin, sorbitol, sucrose, trehalose and xylose was determined on 96 strains of Bacillus anthracoides, 3; Bacillus badius, 5; Bacillus brevis (3), Bacillus circulans (4), Bacillus coagulans (3), Bacillus lentus (6); Bacillus marcerans (3), Bacillus pantothenticus (15), Citrobacter amalonaticus (3), Citrobacter diversus (1), Enterobacter agglomerans (2), Enterobater gregoviae (1), Enterococcus asacchrolyticus (1), Enterococcus avium (4), Enterococcus caecorum (8), Enterococcus gallinarum (2), Enterococcus malodoratus (1), Enterococcus mundtii (1), Enterococcus raffinosus (4), Ervinia ananas (1), Klebsiella oxytoca (2), Microcccus luteus (2), Morganella morganii (2), Proteus mirabilis (9), Proteus vulgaris (6), Providencia rettgeri (3) and Pseudomonas aeruginosa (1). Of the 19 sugars tested on 96 strains only glycerol, lactose, maltose, mannitol, raffinose and xylose had bacteriostatic effect against 1, 1, 6, 4, 4 and 3 strains, respectively. Of the 18 strains sensitive to one or other sugar none of the strains was sensitive to more than one sugar except a strain of C. diversus sensitive to raffinose and xylose. Sugar sensitive strains belonged to 11 species of Bacillus (5), Citrobacter (1), Enterococcus (3), Proteus (1) and Providencia (1) genus.
    Full-text · Article · Jul 2014
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    • "Associated bee brood (larvae and pupae), which are consumed simultaneously, also provide high amounts of protein, fat, and B-vitamins (Finke, 2005). As a result of such high micronutrient diversity, honey has many functional properties desired by humans, such as long preservation time (Nagai et al., 2006) and antimicrobial (Molan, 1992a,b; Cooper et al., 1999), antiviral, antiparasitory, antiinflammatory , and antioxidant effects (Bogdanov et al., 2008). Thus, it is perhaps unsurprising that honey is a prized resource among hunter-gatherers (Ichikawa, 1981; O'Dea et al., 1991; Chagnon, 1992; Marlowe and Berbesque, 2009), particularly in rainforests where carbohydrate-rich food resources are scarce (Hart and Hart, 1986; Headland, 1987). "
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    ABSTRACT: Walking and running have dominated the literature on human locomotor evolution at the expense of other behaviors with positive and negative fitness consequences. For example, although modern hunter-gatherers frequently climb trees to obtain important food resources in the canopy, these behaviors are seldom considered within the existing framework of primate positional behavior. As a result, inferences about the arboreal performance capabilities of fossil hominins based on a resemblance to humans may be more complicated than previously assumed. Here we use ethnographic reports of human tree climbing to critically evaluate hypotheses about the performance capabilities of humans in trees compared with other primates. We do so by reviewing the ecological basis of tree climbing behavior among hunter-gatherers and the diversity of human climbing techniques and styles. Results suggest that the biological and adaptive significance of human climbing has been underestimated, and that some humans are surprisingly competent in trees, particularly during vertical climbing and activities in the central core of trees. We conclude that while hominins evolved enhanced terrestrial locomotor performance through time, such shifts may have imposed only minor costs on vertical climbing abilities. The diversity of the locomotor repertoire of modern humans must therefore be taken into account when making form-function inferences during the behavioral reconstruction of fossil hominins.
    Full-text · Article · Jun 2014 · Journal of Human Evolution
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