The role of zinc in wound healing

ArticleinAdvances in wound care: the journal for prevention and healing 12(3):137-8 · May 1999with25 Reads
Source: PubMed
Abstract
Zinc deficiency has been associated with delayed wound healing. Because zinc deficiency may be common in the United States, foods rich in zinc, as well as all other essential nutrients, should be promoted in the diet of patients who are malnourished or at risk for malnutrition.
    • "Zn deficiency has been shown to be prevalent in a number of studies investigating Zn status in elderly populations [9][10][11]. Deficiency of Zn may cause impaired immune function [12][13][14], delayed wound healing [15] , de- pression [16], impaired cognitive function [17], and increased oxidative stress [18, 19]. As Zn deficiency may have serious implications for the health of aging individuals, it is important to maintain adequate Zn nutriture within this population. "
    [Show abstract] [Hide abstract] ABSTRACT: An increased intake of Zinc (Zn) may reduce the risk of degenerative diseases but may prove to be toxic if taken in excess. This study aimed to investigate whether Zinc carnosine supplement can improve Zn status, genome stability events and Zn transporter gene expression in an elderly (65-85y) South Australian cohort with low plasma Zn levels. A 12 week placebo-controlled intervention trial was performed with 84 volunteers completing the study, (Placebo, n = 42) and (Zn group, n = 42). Plasma Zn was significantly increased (p<0.05) by 5.69% in the Zn supplemented group after 12 weeks. A significant (p<0.05) decrease in the micronucleus frequency (-24.18%) was observed for the Zn supplemented cohort relative to baseline compared to the placebo group. Reductions of -7.09% for tail moment and -8.76% for tail intensity were observed for the Zn group (relative to baseline) (p<0.05). Telomere base damage was found to be also significantly decreased in the Zn group (p<0.05). Both MT1A and ZIP1 expression showed a significant increase in the Zn supplemented group (p<0.05). Zn supplementation may have a beneficial effect in an elderly population with low Zn levels by improving Zn status, antioxidant profile and lowering DNA damage. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.
    Article · Mar 2015
    • "In vivo quercetin release is also reported to have anti-inflammatory effect on injury (Monica et al., 2005) The element Zinc was found to be in higher in concentration in olive oil when compared to that in honey. Prassad (1995) reported that zinc is involved in protein synthesis and deficiency of this element in the body causes delay in wound healing (Heinemann, 1996), while high ingestion results in interference with copper absorption and indirectly interferes with wound healing (Marti and Allred, 1999). In this study, Zinc was found in optimum amount which is similar to daily requirement by a 4-8 year old human. "
    [Show abstract] [Hide abstract] ABSTRACT: The phytochemical and elemental constituents of honey and olive oil and their relationships with wound healing were studied in New Zealand rabbits. Phytochemical analysis showed the presence of Carbohydrates, monosaccharide, reducing sugar, terpenoid, saponin, saponin glycoside, flavonoids, and alkaloid in honey, while olive oil had only cardiac glycoside and terpenoids.Elemental analysis showed the presence of higher concentration of potassium (288.3mg/l), and low concentration of manganese (0.04mg/l), iron (1.55mg/l), copper (0.66mg/l) and nickel (0.001mg/l) in honey than olive oil. However, olive oil has higher concentration of calcium (225.3mg/l) and zinc (5.22mg/l) than in honey. The wound healing effects of honey and olive oil were determined by inflicting a 2 mm incisional wound on the thigh muscle of 18 New Zealand rabbits. The rabbits were grouped into six groups (A-F) which were topically administered of honey (A), olive oil (B), honey and olive oil mixture (C), iodine and methylated spirit (D) and penicillin (E).Group F was undressed and untreated and served as negative control. Healing and scar tissue formation was monitored over a period of 10 days by measuring the wound closure daily. It was observed that group B and D had complete resolution with minimal scar tissues by day six. Other groups had a longer resolution time of up to 9 days post incision. The study therefore, showed olive oil alone and a combination of iodine and methylated spirit both aided greatly in dehiscence of uncontaminated surgical wounds in New Zealand rabbits.
    Full-text · Article · Jun 2014 · Acta biomaterialia
    • "The substitution of silicate ions into the HA crystal lattice is hypothesized to significantly influence surface wettability and increase the surface charge, which results in enhancement of the expression of various proteins, such as ALP, type I collagen and osteocalcin by osteoblasts [313]. Zinc, as a component of many enzymes, is an essential trace element for tissue regeneration [328], particularly protein and DNA synthesis and cell proliferation [329,330]. It was reported that Zn-containing apatite layers on Ti rods increased fibroblast and osteoblast proliferation and differentiation in vitro more rapidly than the apatite layer [330] . "
    [Show abstract] [Hide abstract] ABSTRACT: A systematic analysis of results available from in vitro, in vivo, and clinical trials on the effects of biocompatible CaP coatings is presented. An overview of the most frequently used methods to prepare CaP-based coatings was conducted. Dense, homogeneous, highly adherent, and biocompatible CaP or hybrid organic/inorganic CaP coatings with tailored properties can be deposited. It has been demonstrated that CaP coatings have a significant effect on the bone regeneration process. In vitro experiments using different cells (e.g. SaOs2, hMSCs, and osteoblast-like cells) have revealed that CaP coatings enhance cellular adhesion, proliferation, and differentiation to promote bone regeneration. However, in vivo, the exact mechanism of osteogenesis in response to CaP coatings is unclear, indeed there are conflicting reports of the effectiveness of CaP coatings with results ranging from highly effective to no significant or even negative effects. This review will therefore highlight progress in CaP coatings for orthopaedic implants and discuss the future research and use of these devices. Currently, an exciting area of research is in bioactive hybrid composite CaP-based coatings containing both inorganic (CaP coating) and organic (collagen, BMPs, RGD etc.) components with the aim of promoting tissue ingrowth and vascularisation. Further investigations are necessary to reveal the relative influences of implant design, surgical procedure, and coating characteristics (thickness, structure, topography, porosity, wettability etc) on the long-term clinical effects of hybrid CaP coatings. In addition to commercially available plasma spraying, other effective routes for the fabrication of hybrid CaP coatings for clinical use still need to be determined and current progress is discussed.
    Full-text · Article · Nov 2013
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