Relationships between Obesity and DSM-IV Major Depressive Disorder, Suicide Ideation, and Suicide Attempts: Results from a General Population Study

Division of Epidemiology, Joseph L. Mailman School of Public Health, Columbia University, New York, NY, USA.
American Journal of Public Health (Impact Factor: 4.55). 03/2000; 90(2):251-7. DOI: 10.2105/AJPH.90.2.251
Source: PubMed


This study sought to test the relationships between relative body weight and clinical depression, suicide ideation, and suicide attempts in an adult US general population sample.
Respondents were 40,086 African American and White participants interviewed in a national survey. Outcome measures were past-year major depression, suicide ideation, and suicide attempts diagnosed according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. The primary predictor was relative body weight, treated both continuously (i.e., body mass index [BMI]) and categorically in logistic regression analyses. Covariates included age, income and education, disease status, and drug and alcohol use.
Relative body weight was associated with major depression, suicide attempts, and suicide ideation, although relationships were different for men and women. Among women, increased BMI was associated with both major depression and suicide ideation. Among men, lower BMI was associated with major depression, suicide attempts, and suicide ideation. There were no racial differences.
Differences in BMI, or weight status, were associated with the probability of past-year major depression, suicide attempts, and suicide ideation. Longitudinal studies are needed to differentiate the causal pathways and mechanisms linking physical and psychiatric conditions.

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    • "However, recurrence intervention is challenging and there exists little evidence to guide clinical practice. Previous studies have identified a number of risk factors for recurrence of suicidal ideation/attempt, such as age, race, sex, sexual orientation (Boeninger et al., 2010; Wang et al., 2011; Irwin et al., 2014), and increasing body mass index (BMI) (Carpenter et al., 2000). Stressful events or circumstances , including poverty, unemployment, living situation (including whether or not there are infants or children in the home), loss of loved ones, arguments with family or friends, a breakdown in relationships and legal or work-related problems (Platt, 1984; Kaltiala-Heino et al., 1999; Cavanagh et al., 1999; Thacore and Varma, 2000; Jacobs and Brewer, 2004), often act as " triggers " to suicide among people who are predisposed or vulnerable to selfharm . "
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    ABSTRACT: Background: Suicidal ideation is one of the strongest predictors of recent and future suicide attempt. This study aimed to develop and validate a risk prediction algorithm for the recurrence of suicidal ideation among population with low mood METHODS: 3035 participants from U.S National Epidemiologic Survey on Alcohol and Related Conditions with suicidal ideation at their lowest mood at baseline were included. The Alcohol Use Disorder and Associated Disabilities Interview Schedule, based on the DSM-IV criteria was used. Logistic regression modeling was conducted to derive the algorithm. Discrimination and calibration were assessed in the development and validation cohorts. Results: In the development data, the proportion of recurrent suicidal ideation over 3 years was 19.5 (95% CI: 17.7, 21.5). The developed algorithm consisted of 6 predictors: age, feelings of emptiness, sudden mood changes, self-harm history, depressed mood in the past 4 weeks, interference with social activities in the past 4 weeks because of physical health or emotional problems and emptiness was the most important risk factor. The model had good discriminative power (C statistic=0.8273, 95% CI: 0.8027, 0.8520). The C statistic was 0.8091 (95% CI: 0.7786, 0.8395) in the external validation dataset and was 0.8193 (95% CI: 0.8001, 0.8385) in the combined dataset. Limitations: This study does not apply to people with suicidal ideation who are not depressed. Conclusions: The developed risk algorithm for predicting the recurrence of suicidal ideation has good discrimination and excellent calibration. Clinicians can use this algorithm to stratify the risk of recurrence in patients and thus improve personalized treatment approaches, make advice and further intensive monitoring.
    Full-text · Article · Dec 2015 · Journal of Affective Disorders
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    • "A long list of health problems includes diabetes (Mokdad et al, 2000), hypertension, coronary artery disease, stroke (Pi-Sunyer et al, 1993), hyperlipidemia, gall bladder and liver diseases and osteoarthritis (Flegal et al, 1998). This list expends to include depression (Carpenter et al, 2000), impaired quality of life (QOL) gynecological problems (abnormal menses, infertility) and disability for women (Han et al, 1998), increased early deaths are linked with obesity (Calle et al, 1999; Pi-Sunyer, 1991; Pi-Sunyer, et al, 1998). "
    Dataset: 18-SUP-220

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    • "As such, more research is needed to explore these links within a population of women with PCOS. Moreover, Carpenter et al. (2000) found that obesity was associated with an increased risk of depression and suicidal ideation among women in the United States. Similarly, Ekbäck et al. (2009) report that women in their study, who suffered from hirsutism, had also contemplated suicide as a way of escaping their condition. "
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    ABSTRACT: Polycystic ovary syndrome is an endocrine disorder affecting 1 in 10 women. Women with polycystic ovary syndrome can experience co-morbidities, including depressive symptoms. This research explores the experience of living with polycystic ovary syndrome and co-morbidities. Totally, 10 participants with polycystic ovary syndrome took part in Skype™ interviews and analysed using thematic analysis. Four themes emerged from the data: change (to life plans and changing nature of condition); support (healthcare professionals, education and relationships); co-morbidities (living with other conditions and depression, self-harm and suicidal ideation) and identity (feminine identity and us and them). The findings highlight the need for screening of women with polycystic ovary syndrome for depressive disorders.
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