... Studies utilizing explant or organotypic culture systems have been proved useful in determining whether cannabinoids/endocannabinoids can reduce excitotoxicity in ex vivo models of epileptic activity. CBD attenuated kainite mediated CA3 injury in rat organotypic hippocampal slice cultures (OHSCs) Leweke et al., 2007;Webb et al., 2008;Montgomery et al., 2016;Cui et al., 2017;Campbell et al., 20212-Arachidonoylglycerol 2-AG CB1, CB2 Cabral et al., 2008Hohmann et al., 2019;Campbell et al., 2021 N- Webb et al., 2008;Duncan et al., 2009;Garg et al., 2010;Hohmann et al., 2019;Im, 2021 Howlett et al., 1984;Hampson et al., 1998;Baker et al., 2000;van der Stelt et al., 2001;Kozela et al., 2013;Aguado et al., 2021;Landucci et al., 2021;Lana et al., 2022 Cannabidiol CBD CB2, GPR55, PPARγ, TRPV2, 5HTA1, direct antioxidant Hampson et al., 1998;Jones et al., 2010;Ruiz-Valdepeñas et al., 2011;Kozela et al., 2013;Sun et al., 2017;da Silva et al., 2018;Hohmann et al., 2019;Bouskila et al., 2021;Landucci et al., 2021Landucci et al., , 2022Lana et al., 2022;Patel et al., 2022 Levonantradol (CP 50,556- Nagayama et al., 1999;Baker, et al., 2000;Bilsland et al., 2006;Solbrig et al., 2010 ...