Antimicrobial activity of methanolic extract of Solanum torvum fruit. Fitoterapia

Department of Veterinary Pathology and Microbiology, University of Nigeria, Nsukka, Nigeria.
Fitoterapia (Impact Factor: 2.35). 05/2000; 71(2):187-9. DOI: 10.1016/S0367-326X(99)00139-2
Source: PubMed


The methanolic extract of Solanum torvum fruit showed a wide spectrum of antimicrobial activities against human and animal clinical isolates.

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    • "Solanum torvum contains a number of potential pharmacologically active chemicals like isoflavonoid sulphate and steroidal glycosides (Yahara et al. 1996; Arthan et al. 2002), chlorogenone and neochlorogenone (Cuervo et al. 1991), triacontane derivatives (Mahmood et al. 1983, 1985), 22-b-O-spirostanol oligoglycosides (Iida et al. 2005) and 26-O-b-glucosidase (Arthan et al. 2006). Antimicrobial activity of the leaf and fruit of this plant have been previously reported (Chah et al. 2000; Balachandran et al. 2012; Lalitha et al. 2010). Balachandran et al. (2012) reported the antimicrobial and antimycobacterial activities of methyl caffeate isolated from S. torvum fruit. "
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    ABSTRACT: Aims: The main objective of this study was to investigate the antifungal effect of Solanum torvum leaves against different field and storage fungi, and to identify its active compound. Also, to evaluate in vitro and in vivo inhibitory efficacy on toxigenic strains of Aspergillus flavus and Fusarium verticillioides. Methods and results: Leaves of S. torvum were sequentially extracted with petroleum ether, toluene, chloroform, methanol and ethanol. The antifungal compound isolated from chloroform extract was identified as torvoside K based on spectral analysis. The antifungal activity of chloroform extract and torvoside K was determined by broth microdilution and poisoned food techniques. The minimum inhibitory concentration (MIC), minimum fungicidal concentration (MFC) and zone of inhibition (ZOI) were recorded. Further, inhibitory effects of chloroform extract and torvoside K on growth of A. flavus and F. verticillioides, and their toxin productions were evaluated using in vitro and in vivo assays. Torvoside K showed the significant activity against tested fungi with ZOIs and MICs ranging from 33.4 to 87.4% and 31.25-250 μg ml(-1) , respectively. Further, Torvoside K showed concentration-dependent antimycotoxigenic activity against aflatoxin B1 and fumonisin B1 production by A. flavus and F. verticillioides, respectively. Conclusions: It was observed that the compound torvoside K significantly inhibited the growth of all fungi tested. Growth of A. flavus and F. verticillioides, and aflatoxin B1 and fumonisin B1 productions were completely inhibited in vitro and in vivo by torvoside K with increasing concentration. Significance and impact of the study: Control of mycotoxigenic fungi requires compounds that able to inhibit both fungal growth and mycotoxin production. The antimycotoxigenic potential of torvoside K of S. torvum is described in this study for the first time. The results indicate the possible use of S. torvum as source of antifungal agents against post-harvest fungal infestation of food commodities and mycotoxin contaminations. This article is protected by copyright. All rights reserved.
    Full-text · Article · Sep 2015 · Journal of Applied Microbiology
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    • "However, most AMPs are found high amount in plant seeds and some of these peptides were isolated for molecular, biochemical as well as structural studies (Odintsova et al., 2007). Members of the family Solanaceae are shown to have the growth inhibition ability toward bacteria, fungi and virus (Chah et al., 2000; Arthan et al., 2002; Wiart et al., 2004). "
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    ABSTRACT: Solanum stramonifolium Jacq. fruit is a commonly found vegetable and herb in Thailand. Its seed aqueous extract was investigated for antibacterial activity by disc diffusion method, protein profile and protein purification. Its seed aqueous extract showed very good inhibition against pathogenic bacteria both gram positive including Stapyllococcus aureus, Bacillus licheniformis, B. subtilis and Xanthomonas sp. and gram negative bacteria including Pseudomonas aeruginosa and Salmonella typhi. Tris-tricine SDS-PAGE revealed major protein bands approximately 10.2, 15.7 and 21.5 kDa. Partial purification by Hitrap Q XL and SOURCE 15RPC column chromatography revealed that the active proteins might bear negative charges. A strong antibacterial activity suggests this plant species could be a good source for antibacterial agents. Further works on pure active compounds characterizations such as molecular structure and bacterial killing mechanism are still needed.
    Full-text · Article · Jan 2012 · International Journal of Agriculture and Biology
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    • "Solanum torvum (family Solanaceae) also known as 'top na aka' in the Batoufam language, is a plant used in Cameroonian folk medicine for the treatment of fever, wound healing and tooth decay [25]. It is reported to have anti-microbial, anti-viral [26,27] and haemostatic properties [27]. A study carried out in Peru on 510 plants showed that 11 species were identified for the treatment of infection, 59 species had anti-inflammatory properties and 43 were used to treat wounds and had haemeostatic properties [28]. "
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    ABSTRACT: The extraction of the teeth by traditional healers in Cameroon is an established cultural practice in the central region of the Cameroon. Traditional healers (TH) use herbs and crude un-sterilized instruments and tools for the tooth extraction procedure. The present study investigates the knowledge and practices of traditional healers regarding tooth extraction and the management of its complications. A cross sectional design utilizing semi-structured questionnaires was used to collect the data from traditional healers and their patients. Sixteen traditional healers (TH) were interviewed. All were male and the majority were between 25-35 years old. The most important reason given for the removal of a tooth was "if it has a hole". All reported using herbs to control bleeding and pain after extractions. Only 20% used gloves between patients when extracting a tooth and just over a third (31.3%) gave post-operative instructions. Eighty seven percent managed complications with herbs and 62.5% reported that they would refer their patients to a dentist whenever there are complications. Only a third (31.3%) was familiar with the basic anatomy of a tooth and more than half (56.3%) reported that tooth extractions are the only treatment for dental problems.One hundred and fifty patients were interviewed with a mean age of 29 years. More than two thirds were in the 21-30 year age group and just over half were male. Sixty six percent reported that they visited the TH because it is cheap, 93.3% were satisfied with the treatment they received while 95.3% reported said they never had a problem after an extraction. Tooth extractions using medicinal plants is well established in Lekie division, Cameroon. Infection control during extraction is not the norm. Traditional healers are willing to co-operate with oral health workers in improving the oral health of their patients. Mutual cooperation, collaboration and integrating TH into primary oral health care services need to be increased.
    Full-text · Article · May 2011 · Journal of Ethnobiology and Ethnomedicine
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