Article

Placebo-Controlled Study of Fluvoxamine in the Treatment of Patients With Compulsive Buying

Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, Georgia, USA.
Journal of Clinical Psychopharmacology (Impact Factor: 3.24). 07/2000; 20(3):362-6. DOI: 10.1097/00004714-200006000-00012
Source: PubMed

ABSTRACT

Compulsive buying is a syndrome characterized by the impulsive and/or compulsive buying of unneeded objects that results in personal distress, impairment in vocational or social functioning, and/or financial problems. Results from a two-site, double-blind, placebo-controlled 13-week trial of fluvoxamine are presented. Subjects had problematic buying behavior that they could not control for the previous 6 months or longer and met DSM-IV criteria for impulse control disorder-not otherwise specified (ICD-NOS) and the University of Cincinnati criteria for compulsive buying. Assessments included clinician-rated scales-the Yale-Brown Obsessive Compulsive Scale modified for compulsive buying, the Clinical Global Impression Scale, the Global Assessment of Functioning, and the Hamilton Rating Scale for Depression-and patient self-reports using daily diaries, which measured episodes of compulsive buying. Forty-two subjects gave informed consent, with 37 subjects providing evaluable information and 23 completing the study. Current or past psychiatric comorbidity was present in 74% of subjects. Intent-to-treat and completer analyses failed to show a significant difference between treatments on any measures of outcome. A high placebo-response rate, possibly from the behavioral benefits of maintaining a daily diary, prevents any definitive statement on the efficacy of fluvoxamine in treating compulsive buying.

Download full-text

Full-text

Available from: Charles B Nemeroff
  • Source
    • "People with CBD in this pilot study were similar demographically and clinically to those described by other investigators, and their disorder was of moderate severity (Christenson et al., 1994; McElroy et al., 1994; Ninan et al., 2000; Miltenberger et al., 2003; Koran et al., 2003, 2007). In short, CBD was primarily a disorder of middle-aged women who had struggled with the condition for nearly 17 years. "
    [Show abstract] [Hide abstract]
    ABSTRACT: We examined the neuropsychological performance of people with compulsive buying disorder (CBD) and control subjects, along with trait impulsivity, symptoms of attention deficit hyperactivity disorder (ADHD), and selected personality characteristics. Subjects received a comprehensive neuropsychological test battery, depression and ADHD symptom assessment, the Barratt Impulsiveness Scale, and a version of the Temperament and Character Inventory. Persons with CBD (n=26) and controls (n=32) were comparable in terms of age, sex, and years of education. Subjects with CBD had a mean age of 36.3 years (S.D.=15.7) and an age at onset of 19.7 years (S.D.=7.0). Compulsive buyers had more lifetime mood, anxiety, and impulse control disorders. People with Compulsive buying performed significantly better on the Wechsler Abbreviated Scale of Intelligence Picture Completion task, a test of visual perception; otherwise, there were no consistent differences in neuropsychological measures. They also had elevated levels of self-reported depression, ADHD symptoms, trait impulsivity, and novelty seeking. In conclusion, compulsive buyers have greater lifetime psychiatric comorbidity than controls, and higher levels of self-rated depression, ADHD symptoms, trait impulsivity, and novelty seeking. The present study does not support the notion that there is a pattern of neuropsychological deficits associated with CBD.
    Full-text · Article · Jul 2012 · Psychiatry Research
  • Source
    • "For example, Black, Monahan, and Gabel (1997) reported the results of an open-label trial in which subjects given the SSRI fl uvoxamine improved. Yet two subsequent randomized controlled trials found fl uvoxamine treatment no better than placebo ( Black, Gabel, Hansen, & Schlosser, 2000 ; Ninan et al., 2000 ), although people in both treatment cells improved. Koran, Chuang, Bullock, and Smith (2003) reported that subjects with CB improved with open-label citalopram, another SSRI. "
    [Show abstract] [Hide abstract]
    ABSTRACT: In this chapter we focus on pathological gambling, compulsive buying, kleptomania, compulsive sexual behavior, and Internet addiction. We have selected these behaviorally expressed conditions because scientists and others writing about behavioral addictions have described common elements that link them with substance addiction. In the following sections, we describe the disorders in turn as well as both their common and unique distinguishing features. (PsycINFO Database Record (c) 2012 APA, all rights reserved)
    Full-text · Chapter · Apr 2012
  • Source
    • "People with CBD in this pilot study were similar demographically and clinically to those described by other investigators, and their disorder was of moderate severity (Christenson et al., 1994; McElroy et al., 1994; Ninan et al., 2000; Miltenberger et al., 2003; Koran et al., 2003, 2007). In short, CBD was primarily a disorder of middle-aged women who had struggled with the condition for nearly 17 years. "

    Full-text · Article · Jan 2012 · Addiction Research and Theory
Show more