Early Bactericidal Activity of Paromomycin (Aminosidine) in Patients with Smear-Positive Pulmonary Tuberculosis

Department of Pharmacy Practice , University of Illinois at Chicago, Chicago, Illinois, United States
Antimicrobial Agents and Chemotherapy (Impact Factor: 4.48). 01/2001; 44(12):3285-7. DOI: 10.1128/AAC.44.12.3285-3287.2000
Source: PubMed


The early bactericidal activity of the aminoglycoside paromomycin (aminosidine) in doses of 7.5 and 15 mg/kg of body weight
was measured in 22 patients with previously untreated smear-positive pulmonary tuberculosis. The fall in log10 CFU per milliliter of sputum per day during the first 2 days of treatment for 7 patients receiving a paromomycin dosage of
7.5 mg/kg/day was 0.066, with a standard deviation (SD) of 0.216 and confidence limits from −0.134 to 0.266, and that for
15 patients receiving 15 mg/kg/day was 0.0924, with an SD of 0.140 and confidence limits from 0.015 to 0.170. The difference
between the mean and zero was not significant for the 7.5-mg/kg dose group but was significant for the 15-mg/kg dose group
(t = 2.55, P = 0.023). Since paromomycin has no cross-resistance with streptomycin and has no greater toxicity than other aminoglycosides,
these results suggest that it has the potential to substitute for streptomycin in antituberculosis regimens and may be a particularly
valuable addition to the drug armamentarium for the management of multidrug-resistant tuberculosis.

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    Preview · Article · Jul 2002 · Clinical Microbiology and Infection
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