Focal Adhesion Kinase: A regulator of focal adhesion dynamics and cell movement

Department of Microbiology, Health Science Center, University of Virginia, Charlottesville, Virginia, VA 22908, USA.
Oncogene (Impact Factor: 8.46). 12/2000; 19(49):5606-13. DOI: 10.1038/sj.onc.1203877
Source: PubMed


Engagement of integrin receptors with extracellular ligands gives rise to the formation of complex multiprotein structures that link the ECM to the cytoplasmic actin cytoskeleton. These adhesive complexes are dynamic, often heterogeneous structures, varying in size and organization. In motile cells, sites of adhesion within filopodia and lamellipodia are relatively small and transient and are referred to as 'focal complexes,' whereas adhesions underlying the body of the cell and localized to the ends of actin stress fibers are referred to as 'focal adhesions'. Signal transduction through focal complexes and focal adhesions has been implicated in the regulation of a number of key cellular processes, including growth factor induced mitogenic signals, cell survival and cell locomotion. The formation and remodeling of focal contacts is a dynamic process under the regulation of protein tyrosine kinases and small GTPases of the Rho family. In this review, we consider the role of the focal complex associated protein tyrosine kinase, Focal Adhesion Kinase (FAK), in the regulation of cell movement with the emphasis on how FAK regulates the flow of signals from the ECM to the actin cytoskeleton.

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Available from: Joan M Taylor
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    • "In addition, recruitment of Focal adhesion kinase (FAK)/Src complex mediates and regulates the signaling events downstream of integrin-dependent pathway [27]. The cytoplasmic protein tyrosine kinase, FAK, is involved in integrin-mediated signal transduction and plays an important role in the control of cell spreading, migration, and survival [83]. Src/FAK mutually regulates the activity of each other and promotes normal and cancer cell migration by regulating focal adhesion formation and turnover through multiple signaling connections [41]. "
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    • "Before beginning to grow or differentiate, anchoragedependent cells have to spread on the extracellular matrix (ECM), a process mediated by a set of cell-adhesion proteins that associate with numerous cytoskeletal and signaling proteins to form focal adhesions (FAs) (Parsons et al., 2000; Gaus et al., 2006). Integrin plays important role in cell spreading (Bhadriraju and Hansen, 2002; Ekblom et al., 2003), its binding to the ECM, followed by its clustering, inducing autophosphorylation of the focal adhesion kinase (FAK), which is one of the major kinases found in FAs implicated in the FA signaling (Wei et al., 1999; Weisner et al., 2005; Goetz et al., 2008). "
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