Article

Gene Therapy for Vein Graft Disease

Division of Cardiovascular Surgery, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
Current Cardiology Reports (Impact Factor: 1.93). 02/2001; 3(1):22-8. DOI: 10.1007/s11886-001-0006-0
Source: PubMed

ABSTRACT

In conclusion, much work has focused on the principles of gene transfer, optimization of methods, and candidate genes. Specifically for human saphenous veins, nitric oxide synthase and TIMI have been most fully evaluated. Gene transfer of nitric oxide synthase has been demonstrated to increase nitric oxide production and reduce neointimal hyperplasia in human SVG.
E2F decoy oligodeoxynucleotide has been used in humans undergoing coronary artery bypass grafting, but no significant difference was observed in graft patency, neointimal hyperplasia, or myocardial infarctions.

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