Inflammatory myofibroblastic tumor of small bowel wall in childhood: Report of a case and a review of the literature

ArticleinPathology International 51(1):47-9 · February 2001with4 Reads
DOI: 10.1046/j.1440-1827.2001.01158.x · Source: PubMed
Benign intestinal tumors are rare in children, however we describe an inflammatory myofibroblastic tumor (IMT) of the jejunum in a 2-year-old girl who presented with an intestinal obstruction. During laparotomy, an annular mass around the jejunum was resected, from which a histological diagnosis of IMT was made. A review of the literature for this rare entity emphasizes the importance of histological confirmation of its benign nature. Because of the risk of local recurrence, IMT cases should have a long-term follow up.
    • "It is sometimes difficult to distinguish IMT from advanced malignant tumors mainly because the mass imitates malignant tumors [8]. The initial diagnosis can be done with some laboratory markers or primary radiography; however, surgical resection and transfer of pathologic samples would have an important role in the diagnosis of this kind of tumor compared with other similar cases [12]. All the patients undergoing surgical operations were advised long-term follow-ups in order to investigate the risk of recurrence [5]. "
    [Show abstract] [Hide abstract] ABSTRACT: Introduction: Inflammatory myofibroblastic tumor (IMT) is a rare benign tumor. Usually seen in children and adolescents, this inflammatory tumor can affect all the organs. Presentation of case: In this case, a five-year-old child experienced the sudden onset of symptoms and the enlargement of abdominal mass 20 days before referral. The patient did not have any symptoms of nausea, vomit, and abdominal pain. In the laparotomy, a large and sticky solid mass, attached to the ileum with the mesenteric origin, sized 10×8cm was observed and completely resected. Discussion: This tumor rarely emerges in the small intestine, and there are a few patients with intestinal manifestation. In this case report, the tumor had an origin of the small intestine mesenteric and it had invaded to the ileum. Conclusion: Despite using some radiographic methods such as medical ultrasound and computerized tomography (CT) scan to diagnose the disease, the definitive diagnosis is merely possible thorough complete surgical resection.
    Full-text · Article · Mar 2016
    • "The macroscopic appearance of inflammatory myofibroblastic tumor with a diameter of almost 5.5 cm originated from the distal ileal segments neighboring the appendix. symptoms including abdominal pain, gastric and intestinal mass with occasional obstruction and growth retardation in children [11]. It has been thought that incidental finding of IMT with acute appendicitis was the first case in the English literature. "
    [Show abstract] [Hide abstract] ABSTRACT: Inflammatory myofibroblastic tumor as a rare neoplastic lesion is seen most commonly in the pulmonary system. Beside the presence of limited number of inflammatory myofibroblastic tumors of the gastrointestinal tract in the literature, co-existence with acute appendicitis has not been reported before. A 27-year-old woman admitted to emergency department with acute abdominal pain at the right lower quadrant. The initial diagnosis was as acute appendicitis. Intraoperatively, a mass with a diameter of almost 5 cm originated from the distal ileal segments neighboring the appendix was seen. The patient was managed by segmental resection of the small intestine including the mass with appendectomy. Histologically, there were bundles of spindle cells accompanied by lymphoplasmocytic infiltration. The immunohistochemical studies showed that tumor cells were positive for smooth muscle actin, vimentin, perinuclear activity for anaplastic lymphoma kinase and CD 68. The final pathologic diagnosis was inflammatory myofibroblastic tumor. Concomitant resection of tumoral lesions detected in the neighbor intestinal segments during appendectomy should be considered to diagnose and treat. For the diagnosis of inflammatory myofibroblastic tumor, immunohistochemistry pattern including positivity for actin, vimentin, CD 68 and anaplastic lymphoma kinase plays a crucial role. Therefore, detailed immunohistochemistry analysis should be performed in suspicious cases. Coexistence of inflammatory myofibroblastic tumor located in the gastrointestinal system with acute appendicitis is a rare event. Complete surgical excision should be regarded as the mainstay of the treatment. Long-term follow up with serial imaging techniques is recommended.
    Full-text · Article · Sep 2015
    • "The synonyms are plasma cell granuloma, inflammatory pseudotumor and possibly inflammatory fibrosarcoma. This tumor is characterized by fibroinflammatory and pseudomembranous appearance (Coffin et al., 1995; Demirkan et al., 2001); mostly occurring in children and young adults with a slight female gender predilection (male-to-female ratio being 3:4). Common site of occurrence is the lungs. "
    File · Dataset · Mar 2015 · Annals of Medicine and Surgery
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