A Atypical MELAS syndrome associated with a new mitochondrial tRNA glutamine point mutation

ArticleinNeurology 56(3):405-7 · March 2001with11 Reads
Impact Factor: 8.29 · DOI: 10.1212/WNL.56.3.405 · Source: PubMed

    Abstract

    The authors studied a 47-year-old patient who presented with an association of deafness, acute cerebral stroke-like episode, leukoencephalopathy, and extensive basal ganglia calcifications. Late onset and neuroradiologic findings were atypical for MELAS syndrome (Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Strokelike episodes). A heteroplasmic G to A transition at nucleotide 4332 in the tRNA glutamine gene was identified in the patient's muscle mitochondrial DNA. The pathogenicity of the mutation was shown in single muscle fibers by the correlation between high mutation load and cytochrome c oxidase defect.