Cystic neoplasms of the pancreas: benign to malignant epithelial neoplasms. Surg Clin North Am

Department of Surgery, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA.
Surgical Clinics of North America (Impact Factor: 1.88). 07/2001; 81(3):497-509. DOI: 10.1016/S0039-6109(05)70139-0
Source: PubMed


Clinical presentation and state-of-the-art imaging permit the differentiation of most cystic pancreatic neoplasms not only from other cystic pancreatic disorders but also from one another. The differentiation of serous cystic lesions from the mucinous neoplasms (cystadenoma or carcinoma and IPMT) is crucial because of the radically different biological characteristics of these two neoplasms. Although mucinous cystic neoplasms should be resected because of their premalignant or overtly malignant tendency, most patients with serous neoplasms require no operative intervention unless they are symptomatic. IPMT is best treated by a total pancreatectomy, although lesser subtotal resections should be strongly considered depending on patient age, medical comorbidity, and psychosocial situations.

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    • "Serous cystadenomas comprise 25% of pancreas cystic neoplasms and 1% of all pancreas tumours.2,17 It is usually seen in females in the sixth decade of life (our patient was also 64 years of age) and is mostly asytmptomatic.11 Most of the symptoms are non-specific, such as abdominal pain, nausea, vomiting, and weight loss. "
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    ABSTRACT: Serous cystadenomas are rare tumors comprising 1-2% of exocrine pancreas tumors. They are mostly known as benign conditions but malign transformation as serous cystadenocarcinoma is also reported. It is usually seen in females. Non-specific symptoms, such as abdominal pain or symptoms due to mass affect, are usually seen. A 64-year old female patient was investigated for abdominal pain. Physical and laboratory findings were normal. Abdomen ultrasonography confirmed an 11×9.5 cm solid cystic lesion and abdomen computed tomography scan confirmed a 12×11 cm lobulated cystic solid lesion which had central cystic necrotic areas extending from liver hilus inferiorly. Fine needle biopsy confirmed benign cytology and trucut biopsy of the pancreatic mass reported chronic inflamation. Nevertheless, this mass could have malignant contents and transformation potential. A laparatomy was decided due to patient's symptoms and mass effect. Due to vascular invasion of the tumor, Whipple procedure was performed. The pathology report confirmed serous microcystic adenoma. These rare tumors are usually benign but pre-operative malignity criterias are not identified. There are few differential diagnostic tools for excluding malignity. We suggest surgical resection as best treatment approach for selected cases.
    Full-text · Article · Oct 2012 · Rare tumors
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    • "The incidence of radiologically detected pancreatic cystic neoplasms in screening varied from 0.2% [5] when ultrasonography was used to 0.7% [6] in a study using CT and MRI scans. Serous cystic neoplasms predominantly affect women (65%), with an average age of 62 years (range 35 Á84 years) [7]. They account for 32 Á39% of cystic tumours of the pancreas [8]. "
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    ABSTRACT: Pancreatic carcinoma accounts for the most dismal survival among all malignancies with 5-year survival rates approaching 5%. The reason for this, besides the inherent biologic nature of the disease, is the fact that the patients tend to present late in the disease. We present a review of the current published data on cystic neoplasms of the pancreas, which though rare, constitute an important subgroup of pancreatic neoplasms that have a better prognosis and are potentially curable lesions.
    Full-text · Article · Feb 2007 · HPB
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    • "However, Sarr and his colleagues [1] have classified these rare neoplasms into a more simplified and practical working classification, which is as follows: • serous cystic neoplasms • mucinous cystic neoplasms • intraductal papillary mucin-producing neoplasms • other less common neoplasms. "
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    ABSTRACT: Cystic pancreatic neoplasms are uncommon, but are being seen more frequently due to the widespread use of cross-sectional imaging. In this article, we will address the clinical and imaging features of the more commonly seen neoplasms. Points of differentiation between these neoplasms, the use of cyst fluid analysis and an approach to the incidentally discovered cystic mass will be addressed.
    Preview · Article · Jan 2003 · Cancer imaging : the official publication of the International Cancer Imaging Society
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