A model of visual and musculoskeletal strain associated with computer monitor placement was developed. The main premise of which is that monitor placement decisions must take into consideration development of both visual and musculoskeletal strains. Certain factors in the model that were thought to affect one or both types of strain. or that were considered important to rule out for effect, were tested in a lab setting. These factors were viewing angle (eye level, midlevel, low level), monitor size (14 in., 19 in.), keyboard familiarity (touch typist, nontouch typist), and task (reading, mousing, typing). Outcomes included indicators of visual and musculoskeletal strain, preference, and performance. Muscle activity was generally greater for the low viewing angle, for the standard monitor (14 in.), and for non-touch typists. Participants preferred the midlevel placement. Task performance was slightly diminished with eye-level placement. Results are interpreted in relation to the model and to several hypotheses that were formed to focus the inquiry. Actual or potential applications of this research include monitor placement decisions in the design or modification of computer workstations.