Article

Family History and the Risk of Early-Onset Persistent, Early-Onset Transient, and Late-Onset Asthma

University of California, Los Angeles, Los Ángeles, California, United States
Epidemiology (Impact Factor: 6.2). 10/2001; 12(5):577-83. DOI: 10.1097/00001648-200109000-00019
Source: PubMed

ABSTRACT

Family history of asthma and allergies strongly influences asthma risk in children, but the association may differ for early-onset persistent, early-onset transient, and late-onset asthma. We analyzed the relation between family history and these types of asthma using cross-sectional data from a school-based study of 5,046 Southern California children. Parental and/or sibling history of asthma and allergy were generally more strongly associated with early-onset persistent asthma compared with early-onset transient or late-onset asthma. For children with two asthmatic parents relative to those with none, the prevalence ratio for early-onset persistent asthma was 12.1 [95% confidence interval (CI) = 7.91-18.7] compared with 7.51 (95% CI = 2.62-21.5) for early-onset transient asthma and 5.38 (95% CI = 3.40-8.50) for late-onset asthma. Maternal smoking in pregnancy was predominantly related to the risk of early-onset persistent asthma in the presence of parental history of allergy and asthma, and the joint effects were more than additive (interaction contrast ratio = 3.10, 95% CI = 1.45-4.75). Our results confirm earlier data that parental history of asthma and allergy is most strongly associated with early-onset persistent asthma and suggest that among genetically predisposed children, an early-life environmental exposure, maternal smoking during pregnancy, favors the development of early-onset asthma that persists into later early childhood.

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Available from: Ed Avol, Jul 15, 2015
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    • "Early childhood is a critical time window for subsequent lung health. Adverse childhood environmental exposures can restrain growth[1], modulate lung function[1,2]and induce changes to gene-expression, modulating airway pathophysiology.[3,4]The impact of a range of early life factors have been evidenced such as parental life-style[5,6], nutrition[7]ambient air pol- lution[8,9]or viral infections.[10]Epigenetic "
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    Full-text · Article · Jan 2016 · PLoS ONE
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    • "Children in the 4th, 7th and 10th grades were recruited in 1993 and 1996 and followed through high school graduation. Associations of asthma with housing characteristics, obesity , air pollution, family history and exercise have been previously described (Gaudermanet al., 2005;Gilliland et al., 2003;Kunzli et al., 2003;London, James Gauderman, Avol, Rappaport, & Peters, 2001;McConnell, Berhane, Gilliland, Islam,et al., 2002;McConnell, Berhane, Gilliland London, et al., 2002;McConnell et al., 2006). A detailed description of the selection of communities, subject recruitment and survey methods to assess demographic , household, activity and baseline medical characteristics has also been reported (Peters et al., 1999). "
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