... Simulating extreme conditions in model experiments involving healthy volunteers is one of the few means to disturb homeostasis in order to identify the mechanisms that maintain a constant internal environment and sustain health reserves and the adaptive potential of the body [21][22][23]. Ethically acceptable methods to simulate extreme conditions in Space flight factors: Microgravity [1][2][3][4][5][10][11][12][13] Radiation [14,15] Isolation [32,42,43,78] Exercise [24-28, 30, 35, 37, 94] Overload (take-off/landing) [2,4,18,11] Diet, nutrition [29,31,33,34,101] Artificial atmosphere (hypoxia) [79][80][81][82][83][84][85][86][87][88]93] Noise(> 50 dB) [2,18,11] Vibration [61,11] Changes in pathogen virulence [51] Behavioral changes: disturbance of sleep, interpersonal relations, mental function, stress, depression, emotional changes [52,75,76] Bone and muscle tissue loss [1, 4, 38-40, 47-49, 53, 54, 58-60, 71] Cardiovascular disorders [23,38,50,54,63,64,66,67,[74][75][76] Immune system weakening [6-8, 51, 69, 100, 108] Metabolic disorders [16-17, 29, 31, 55, 56, 98, 101, 107-106] Oncology [14-17, 70, 112] Red blood cell decrease: anemia [108] Ocular problems [16][17][18] experiments involving human subjects are relatively few and include extreme exercise or a decrease in locomotor activity [24][25][26][27][28][29][30]; various diets [31][32][33][34][35], in particular, with changed contents of major nutrients [31,32,36]; and functional loading tests [37]. Several experimental models and methods have been designed to study the physiological changes that are induced by various specific factors during space missions [19,20]. ...