Mantle cell lymphoma presenting as a breast mass

Department of Haematology, Belfast City Hospital, Lisburn Road, Belfast BT9 7AD, Northern Ireland, UK.
Journal of Clinical Pathology (Impact Factor: 2.92). 12/2001; 54(11):883-6. DOI: 10.1136/jcp.54.11.883
Source: PubMed


Breast lymphoma accounts for less than 1% of all non-Hodgkin's lymphomas (NHLs) and approximately 0.1% of all breast neoplasms. Most breast lymphomas are classified as diffuse large B cell or mucosa associated lymphoid tissue (MALT) lymphomas. The case of a 53 year old woman presenting with a breast mass and found to have mantle cell lymphoma is described. Core biopsy of the breast lesion showed a B cell NHL, probably of large cell type and of high grade. Morphological and immunophenotypic analysis of peripheral blood and bone marrow samples suggested a mantle cell lymphoma (MCL). This was confirmed by the detection of a t(11;14) in the bone marrow aspirate and breast tissue by polymerase chain reaction analysis. There have been no previous reports of an MCL presenting as a breast lump. Because a diagnosis of MCL has prognostic and therapeutic implications, this case highlights the need for an awareness of MCL presenting in this way, and the requirement for specialised investigations in its detection.

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Available from: Mark Catherwood, Aug 13, 2015
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    • "The commonest histologies are DLBCL (56–84% of PBL) [4] [5] [8] [9] [28] [50], MZL (9–28%) [2] [5] [25] [28] [51], follicular (10–19%) [2] [9] [51], and Burkitt lymphoma (<6%) [50] [52] [53]. Rarer histologies include anaplastic large cell lymphoma [54], peripheral T-cell lymphoma [55] [56], small lymphocytic lymphoma [2] [25], lymphoplasmacytic lymphoma [2], mantle cell lymphoma [57] [58] [59] and Hodgkin lymphoma (each < 1%) [5]. Here we present an overview of the more important rare subtypes , followed by more detailed evaluation of the pathology and clinical aspects of PB-DLBCL. "
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