Resistance is futile: Assimilation of cellular machinery by HIV-1

ArticleinImmunity 15(5):687-90 · December 2001with7 Reads
Impact Factor: 21.56 · DOI: 10.1016/S1074-7613(01)00238-2 · Source: PubMed


    HIV-1 budding appears to require Vps4 and Tsg101-two proteins that have links to endosomal sorting machinery. A picture emerges wherein divergent viruses recruit endosomal proteins like Tsg101 to gain access to ubiquitin processes that play a crucial role during viral budding.