... Many studies prove that a huge portion of drugs is interacted different foodstuffs, drugs, beverages, juices and environmental chemical reagents [5]. Many drugs interact with fruit juice such as dihydropyridines, terfenadine, saquinavir, cyclosporine, midazolam, triazolam and verapamil, ergotamine, nimodipine, fluvoxamine, codeine, tramadol, oxycodone, hydrocodone, carbamazepine, imatinib, loperamide, losartan, dextromethorphan, repaglinide, buspirone, amiodarone, dronedarone, quinidine, disopyramide, propafenone, carvedilol, cisapride, felodipine, nicardipine, difedipine, nisoldipine, nitrendipine, sildenafil, tadalafil, vardenafil, dihydrocodeine, omeprazole, zolpidem, methadone, trazodone, praziquantel, albendazole, lovastatin, astemizole and mebendazole etc. [6][7][8][9][10][11][12][13][14][15]. In vitro dissolution acted as a key function in liberating the drug from the tablet matrix and marking for consequent gastrointestinal assimilation. ...