Metabolism of dietary essential fatty acids and their conversion to long-chain polyunsaturated metabolites

Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, Texas A&M University, College Station 77843-4474, USA.
Journal of the American Veterinary Medical Association (Impact Factor: 1.56). 07/2002; 220(11):1621-6. DOI: 10.2460/javma.2002.220.1621
Source: PubMed
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    ABSTRACT: Results of this study confirm that dietary supplementation in dogs with a natural source of omega-3 fatty acids (salmon oil), with a docosahexaenoic acid:eicosapentaenoic acid (DHA:EPA) ratio of 1.5:1, increases plasma and red blood cell levels of these fatty acids. Supplementation with this DHA-enriched oil improves the long-chain polyunsaturated fatty acid omega-6:omega-3 (n-6:n-3) ratio, which may benefit dogs of all ages. Studies describing some of the neurologic, renal, cardiovascular, immune, and musculoskeletal effects of elevated blood levels of n-3 fatty acids, especially DHA, are reviewed. The importance of providing an enriched source of DHA, instead of its shorter precursors, is emphasized.
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    ABSTRACT: Fish oil omega-3 fatty acids, mainly eicosapentaenoic acid and docosahexaenoic acid, are used in the management of several diseases in companion animal medicine, many of which are inflammatory in nature. This review describes metabolic differences among omega-3 fatty acids and outlines potential adverse effects that may occur with their supplementation in dogs and cats with a special focus on omega-3 fatty acids from fish oil. Important potential adverse effects of omega-3 fatty acid supplementation include altered platelet function, gastrointestinal adverse effects, detrimental effects on wound healing, lipid peroxidation, potential for nutrient excess and toxin exposure, weight gain, altered immune function, effects on glycemic control and insulin sensitivity, and nutrient-drug interactions.
    Full-text · Article · Jan 2013 · Journal of Veterinary Internal Medicine
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    ABSTRACT: Fatty acids have a number of important roles in the body. These include, among others, serving as a source of fuel, transporting fat-soluble vitamins, serving structural functions as part of cell membranes, and being involved in cell regulation and signaling. Fatty acids are also used for management of disease, giving them a unique role as a nutraceutical, which is a nutrient that has properties of a drug.1,2 The objective of the information reported here is to provide an overview of topics related to fatty acids and to improve general understanding of these topics. & 2015 American Veterinary Medical Association. All rights reserved.
    No preview · Article · Jun 2015 · Journal of the American Veterinary Medical Association