Article

Prevalence of narcolepsy symptomatology and diagnosis in the European general population. Neurology 58, 1826-33

Universität Regensburg, Ratisbon, Bavaria, Germany
Neurology (Impact Factor: 8.29). 07/2002; 58(12):1826-33. DOI: 10.1212/WNL.58.12.1826
Source: PubMed

ABSTRACT

To determine the prevalence of narcolepsy in the general population of five European countries (target population 205,890,882 inhabitants).
Overall, 18,980 randomly selected subjects were interviewed (participation rate 80.4%). These subjects were representative of the general population of the UK, Germany, Italy, Portugal, and Spain. They were interviewed by telephone using the Sleep-EVAL expert system, which provided narcolepsy diagnosis according to the International Classification of Sleep Disorders (ICSD).
Excessive daytime sleepiness was reported by 15% of the sample, with a higher prevalence in the UK and Germany. Napping two times or more in the same day was reported by 1.6% of the sample, with a significantly higher rate in Germany. Cataplexy (episodes of loss of muscle function related to a strong emotion), a cardinal symptom of narcolepsy, was found in 1.6% of the sample. An ICSD narcolepsy diagnosis was found in 0.047% of the sample: The narcolepsy was severe for 0.026% of the sample and moderate in 0.021%.
This is the first epidemiologic study that estimates the prevalence of narcolepsy in the general population of these five European countries. The disorder affects 47 individuals/100,000 inhabitants.

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    • "In the current study, we did not rule out that SP occurred as a symptom of narcolepsy, and shall thus use the term SP rather than ISP (see also, Jalal and Hinton, 2013; Jalal et al., 2014a, b; Jalal et al., in press). We should note however that since narcolepsy is rare occurring in less than one percent of the general population, the vast majority of SP cases reported in this study are bound to represent ISP (Ohayon et al., 2002).] "
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    • "Narcolepsy with cataplexy (NC) is a chronic neurological disease with a prevalence of approximately 0.045% in North America and Europe (Ohayon et al. 2002). The manifestations of NC are excessive daytime sleepiness and cataplexy, and roughly half of patients experience hypnagogic hallucinations and sleep paralysis. "
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    • "Son incidence suit une courbe d'incidence bimodale avec un pic à 15 ans et un second vers 35 ans [5]. Sa prévalence est estimée environ à 0,025 % [6]. Les mécanismes étiopathogéniques de la NSC et de l'HI restent mal connus, contrairement à ceux de la NC. "
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