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Allergic contact dermatitis following exposure to essential oils

Authors:
  • Clinical Trials New Zealand, Waikato Hospital Clinical Campus, Hamilton, New Zealand

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Allergic contact dermatitis from the topical use of essential oils is not widely recognized as an occupational hazard. Four cases of allergic contact dermatitis to essential oils occurring in three aromatherapists and one chemist with a particular interest in aromatherapy are described. All presented with predominantly hand dermatitis and demonstrated sensitization to multiple essential oils. One patient developed a recurrence of cutaneous symptoms following ingestion of lemongrass tea. Workers within this industry should be aware of the sensitization potential of these products and the risk of limiting their ability to continue employment.
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INTRODUCTION
The exposure to essential, or volatile, oils in an occupational
setting is increasing with the burgeoning popularity of
natural therapies in Anglo-Saxon cultures. Aromatherapy is
the use of essential oils topically or by inhalation to promote
physical and psychological well-being.1Essential oils are
aromatic substances that are extracted from many different
plants and a small number of animals, or that can be synthe-
sized from coal and petrolatum.2The oil can be extracted from
plants and flowers by several methods including distillation,
extraction, enfleurage, maceration and expression.2The
composition of essential oils is highly variable. Each oil may
have over 100 constituents; the same botanical species may
produce oils containing differing components and concen-
trations.1The principal constituents of essential oils are
monoterpene and sesquiterpene hydrocarbons, monoterpene
and sesquiterpene alcohols, esters, ethers, aldehydes, ketones
and oxides.1Typically, each oil has several compounds from
each major chemical group.1The spectrum of reported skin
reactions to essential oils includes allergic contact dermatitis,
irritant contact dermatitis, phototoxic reactions and contact
urticaria.3–5 We present four cases of hand dermatitis as a
result of allergic contact dermatitis following exposure to
essential oils.
CASE REPORTS
Case 1
A 52-year-old female masseur and aromatherapist presented
with a 12-month history of hand and later forearm dermatitis.
The rash improved substantially when she was absent from
work and recurred upon her returning. Standard patch testing
was performed using aluminium Finn chambers with read-
ings at 48 and 96 hours, to an extended standard series, a
cosmetic series, a fragrance series and her own massage
oils. The positive reactions are presented in Table 1. The
aromatherapist subsequently developed a small area of
dermatitis on her forearm following ingestion of lemongrass
tea and Thai food.
Case 2
A 46-year-old female masseur and aromatherapist presented
with a 3-year history of hand and forearm dermatitis. The rash
improved upon cessation of her employment. She had a past
history of hayfever and a family history of atopy. Standard
patch testing was performed using aluminium Finn chambers
with readings at 48 and 96 hours to an extended standard
series, a cosmetic series, a fragrance series, a limited plant
series and her own massage oils. The positive reactions are
presented in Table 1. In addition, the patient demonstrated a
positive patch-test reaction to her own massage oil, which
contained a mix of almond, ylang ylang, neroli, sandalwood
and frankincense oils.
Case 3
A 45-year-old natural therapist presented with a 3-year history
of hand dermatitis, which extended to involve her face and
neck 2 weeks prior to presentation. The eruption resolved
completely while on a 2-week holiday. Patch testing to the
Australasian Journal of Dermatology (2002) 43, 211–213
CASE REPORT
Allergic contact dermatitis following exposure
to essential oils
Narelle Bleasel,1Bruce Tate1and Marius Rademaker2
1Skin and Cancer Foundation, Carlton, Victoria, Australia, and
2Health Waikato, Hamilton, New Zealand
SUMMARY
Allergic contact dermatitis from the topical use of
essential oils is not widely recognized as an occupa-
tional hazard. Four cases of allergic contact dermatitis
to essential oils occurring in three aromatherapists and
one chemist with a particular interest in aromatherapy
are described. All presented with predominantly hand
dermatitis and demonstrated sensitization to multiple
essential oils. One patient developed a recurrence of
cutaneous symptoms following ingestion of lemongrass
tea. Workers within this industry should be aware of
the sensitization potential of these products and the risk
of limiting their ability to continue employment.
Key words: Bulgarian rose oil, hand dermatitis,
lavender oil, natural therapist, occupational skin
disease, ylang ylang oil.
Correspondence: Dr B Tate, Skin and Cancer Foundation,
95 Rathdowne St, Carlton, Vic. 3053, Australia.
Narelle Bleasel, MB BS. Bruce Tate, FACD. Marius Rademaker,
FRACP.
Submitted 22 October 2001; accepted 15 January 2002.
European standard series (Chemotechnique, Malmo, Sweden),
antimicrobials, an extended fragrance series and
her own massage oils was performed using IQ chambers
(Chemotechnique), with readings at 48 and 96 hours. The
positive reactions are presented in Table 1.
Case 4
A 29-year-old analytical chemist, with a part-time occupa-
tional interest in aromatherapy and massage, presented with
a 1-month history of hand dermatitis. The rash became more
widespread to involve her face and neck prior to presentation.
Relevant past history included hayfever and scabies. Patch
testing to the European standard series (Chemotechnique),
a cosmetic series, a fragrance series, and the patient’s own
massage oils was performed using IQ chambers (Chemo-
technique) with readings at 48 and 96 hours. The positive
reactions are presented in Table 1.
Reactions were graded according to the International
Contact Dermatitis Research Group grading system.
DISCUSSION
The frequency of allergic contact dermatitis associated with
essential oil usage is unknown and at present there have been
only limited reports of this association in the natural therapy
industry.6–9 This may represent low incidence of sensitization
to these compounds, or a failure to recognize allergic contact
dermatitis within this occupation and subsequent under-
reporting. Allergic contact dermatitis related to essential
oils has been reported in several other occupational groups,
including bar workers,10 citrus fruit pickers,11 a hairdresser,12
a physiotherapist,13 a beautician14 and manufacturers of
cosmetics.15,16
Determining the sensitizing agent responsible for skin
reactions associated with an essential oil is difficult, because
of the many components and their variable concentrations
within an oil.1In addition, the components of an essential oil
often undergo complex interactions that result in reducing
the sensitization potential of an individual compound
when combined in an oil mixture.1,5 This is known as the
quelching effect.1,5 Indeed, a degradation product may be
the sensitizing agent.1,3
The four cases presented developed a delayed type allergy
to essential oils following exposure in an occupational setting.
In all cases, multiple sensitizations were demonstrated.
Case 1 displayed positive patch-test reactions to several
essential oils that she had not previously been exposed to,
including palmarosa, frankincense, rose, neroli and myrrh.
Linalool was a common constituent amongst this group of
sensitizing oils, with the exception of myrrh, implicating
cross-reactivity.17,18 Of note, this patient had a positive patch-
test reaction to lemongrass and described a recurrence of
dermatitis following ingestion of lemongrass-containing foods.
The phenomenon of systemic contact dermatitis has pre-
viously been described in relation to Matricaria chamomilla
tea.19
Case 2 exhibited sensitivity to geraniol, a component of
lavender, rose, geranium, ylang ylang, lemongrass, cananga,
sandalwood and neroli.17,18 This may account for her sensi-
tivity to these products. In addition this patient displayed
sensitivity towards peppermint, laurel and yarrow, products
which do not contain geraniol.17,18 Limonene is a common
component in this second group of oils; however, sensitivity
to this compound was not tested.17,18
Geraniol is a common constituent of the oils case 3 devel-
oped sensitization reactions to;17,18 however, the patient did not
exhibit sensitivity to geraniol. Similarly, the positive reactions
seen in case 4 could be accounted for by sensitivity to geraniol;
however, no primary reaction to geraniol was present.
Of note, three of the four cases presented had positive
patch-test reactions to fragrance mix. The constituents of
fragrance mix are cinnamic alcohol, cinnamic aldehyde,
-amyl cinnamic aldehyde, eugenol, isoeugenol, geraniol,
hydroxycitronella and oak moss.20 Six of these eight fragrance
ingredients are also components of essential oils (including
cinnamic alcohol, cinnamic aldehyde, eugenol, isoeugenol,
geraniol).4Fragrance mix is a common allergen, with approxi-
mately 1% of the unselected population demonstrating sensi-
tivity.21 Patients with positive patch-test reactions to fragrance
mix often react to essential oils. One study demonstrated that
57% of patients with positive reactions to fragrance mix also
reacted to one or more essential oils.22 However, testing solely
with fragrance mix or its constituents will not reliably detect
all patients allergic to essential oils. Patients can be tested to
the commercially available allergens in the Chemotechnique
fragrance series.
The use of essential oil-based products in people’s homes
is also now popular and leading to reports of allergic contact
dermatitis.23–25 Many cosmetics and perfumes contain essen-
tial oils and are likely to be important allergens.5,20,22,26 In
Japan, an increase in the frequency of positive patch tests to
lavender oil was reported between 1990 and 1998.25 A tele-
phone survey of these patients suggested the main source of
exposure to the lavender allergens was products containing
dried lavender flowers.
These cases highlight the importance of allergic contact
dermatitis associated with essential oil exposure in an
occupational setting. It appears that multiple sensitizations
are a common occurrence. Therefore, avoidance of a single
212 N Bleasel et al.
Table 1 Results of patch tests
Test substance Case 1 Case 2 Case 3 Case 4
Fragrance mix + + +
Cananga oil 2.0% –+–+
Geraniol 2.0% +
Geranium oil Bourbon 2.0% + + +
Frankincense 5.0% + NT NT NT
Lavender absolute 2.0% ++++
Lavender oil 2.0% + NT NT NT
Laurel oil 2.0% + NT NT
Lemongrass oil 2.0% + + NT NT
Myrrh 5.0% + NT NT NT
Neroli oil 2.0% + NT NT
Palmarosa 5.0% + NT NT
Peppermint oil 2.0% + NT NT
Rose oil, Bulgarian 2.0% ++++
Sandalwood oil 2.0% + + +
Yarrow + NT NT
Ylang ylang oil 2.0% + + +
+, positive reaction; –, negative reaction; NT, not tested.
oil is unlikely to prevent further episodes of allergic contact
dermatitis. In addition, the concurrent reaction to fragrance
mix may pose further limitations on product selection.
Employees within the aromatherapy and masseur industry
should be aware of the sensitization potential of the oils that
they use in their workplace. Sensitization to essential oils may
have serious ramifications, as the employees may be unable
to continue in their chosen field of work. It is also necessary
to consider allergy to essential oils in clients of aromathera-
pists and people using them at home.
REFERENCES
1. Battaglia S. Essential oil safety. In: The Complete Guide to
Aromatherapy. Virginia: The Perfect Potion, 1995; 123–9.
2. Scheinman PL. Allergic contact dermatitis to fragrance: A review.
Am. J. Contact Dermat. 1996; 7: 65–76.
3. Tisserand R, Balacs T. The skin. In: Essential Oil Safety: A Guide
for Health Care Professionals. Edinburgh: Churchill Livingstone,
1995; 77–89.
4. Alanko K. Aromatherapists. In: Kanerva L, Elsner P, Wahlberg JE,
Maibach HI (eds). Handbook of Occupational Dermatology.
Heidelberg: Springer Verlag, 2000; 811–13.
5. De Groot A, Frosch PJ. Adverse reactions to fragrances: A clinical
review. Contact Dermatitis 1997; 36: 57–86.
6. Bilsland D, Strong A. Allergic contact dermatitis from the essential
oil of French marigold (Tagetes patula) in an aromatherapist.
Contact Dermatitis 1990; 23: 55–6.
7. Selvaag E, Holm J-O, Thune P. Allergic contact dermatitis in an
aromatherapist with multiple sensitisations to essential oils.
Contact Dermatitis 1995; 33: 354–5.
8. Cockayne SE, Gawkrodger DJ. Occupational contact dermatitis in
an aromatherapist. Contact Dermatitis 1997; 37: 306–7.
9. Keane FM, Smith HR, White IR, Rycroft RJG. Occupational allergic
contact dermatitis in two aromatherapists. Contact Dermatitis
2000; 43: 49–51.
10. Cardullo AC, Ruszkowski AM, DeLeo VA. Allergic contact derma-
titis resulting from sensitivity to citrus peel, geraniol and citral.
J. Am. Acad. Dermatol. 1989; 21: 395–7.
11. Audicana M, Bernaola G. Occupational contact dermatitis from
citrus fruits: Lemon essential oils. Contact Dermatitis 1994;
31: 183–5.
12. Brandao FM. Occupational allergy to lavender oil. Contact
Dermatitis 1986; 15: 249–50.
13. Rademaker M. Allergic contact dermatitis from lavender fragrance
in Difflamgel. Contact Dermatitis 1994; 31: 58–9.
14. Romaguera C, Vilaplana J. Occupational contact dermatitis from
ylang-ylang oil. Contact Dermatitis 2000; 43: 251.
15. Kenerva L, Estlander T, Jolanki R. Occupational allergic contact
dermatitis caused by ylang-ylang oil. Contact Dermatitis 1995; 33:
198–9.
16. Rudzki E, Rebandel P, Grzywa Z. Occupational dermatitis from
cosmetic creams. Contact Dermatitis 1993; 29: 210.
17. Price S, Price L. Appendix A. In: Aromatherapy for Health
Professionals, 2nd edn. Edinburgh: Churchill Livingstone, 1999;
314–46.
18. Lawless J. The oils. In: The Encyclopaedia of Essential Oils.
Longmead: Element Books Limited, 1992; 69–194.
19. Rodriguez-Serna M, Sanchez-Motilla JM, Ramon R, Aliaga A.
Allergic and systemic contact dermatitis from Matricaria
chamomilla tea. Contact Dermatitis 1998; 39: 192–3.
20. Larsen W, Nakayama H, Fischer T, Elsner P, Frosch P,
Burrows D et al. Fragrance contact dermatitis: A worldwide
multicenter investigation (Part II). Contact Dermatitis 2001;
44: 344–6.
21. Nielsen NH, Menne T. Allergic contact dermatitis in an
unselected Danish population. Acta Derm. Venereol. 1992; 72:
456–60.
22. Rudzki E, Grzywa Z, Bruo WS. Sensitivity to 35 essential oils.
Contact Dermatitis 1976; 2: 196–200.
23. Weiss RR, James WD. Allergic contact dermatitis from aroma-
therapy. Am. J. Contact Dermat. 1997; 8: 250–1.
24. Schaller M, Korting HC. Allergic airborne contact dermatitis from
essential oils used in aromatherapy. Clin. Exp. Dermatol. 1995;
20: 143–5.
25. Sugiura M, Hayakawa R, Kato Y, Sugiura K, Hashimoto R. Results
of patch testing with lavender oil in Japan. Contact Dermatitis
2000; 43: 157–60.
26. Larsen WG. Perfume dermatitis. J. Am. Acad. Dermatol. 1985; 12:
1–9.
Contact dermatitis to essential oils 213
214 N Bleasel et al.
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