Annexin V-CLIO a nanoparticle for detecting apoptosis by MRI

Center for Molecular Imaging Research, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.
Academic Radiology (Impact Factor: 1.75). 09/2002; 9 Suppl 2(Suppl 2):S310-1.
Source: PubMed
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Available from: Eyk Schellenberger, May 14, 2014
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    • "Nano-sized magnetic resonance imaging (MRI) contrast agents are used for intraoperative imaging in the context of neuro-oncological interventions [11] [16]. In this scheme, detection in NCC is done using, Gadolinium-based nano-particles [18], Iron oxide-based nano-particles or multiple-mode imaging contrast nano-agents [25] [8] [29] [21] [31] [30]. Moreover, detection over the MCC is accomplished using a combination of MRI and biological targeting [13] or optical detection [16] [13] [5]. "
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    • "non-toxicity, biodegradability, biocompatibility) characteristics [1] [2] [3] [4] [5] [6] [7] [8] that empower their prominent application position in diverse fields of medicine. Particles such as cross-linked iron oxide (CLIO) [9] [10], ultrasmall superparamagnetic iron oxide (USPIO) [11] [12] [13], and monocrystalline iron oxide nanoparticles (MIONs) [14] [15] have all been developed as imaging agents in magnetic resonance imaging (MRI). Some of the reported particles are likely to be taken up by macrophages and immune cells and can be used to image lymph nodes and inflammatory tissues. "
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    • "These agents have been used extensively for preclinical work and commercial preparations have been used in clinical trials. CLIO particles represent a stabilized dextran-coated iron oxide nanoparticle preparation specifically designed for targeting [13] [17] [18]. In these particles , the iron oxide core is caged by the cross-linked dextran coating so that there exists no equilibrium between free and iron oxide-associated dextran moieties. "
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