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Tyler WJ, Alonso M, Bramham CR, Pozzo-Miller LD. From acquisition to consolidation: on the role of brain-derived neurotrophic factor signaling in hippocampal-dependent learning. Learn Mem 9: 224-237

Department of Psychology, University of Alabama at Birmingham, Birmingham, Alabama, United States
Learning & Memory (Impact Factor: 3.66). 09/2002; 9(5):224-37. DOI: 10.1101/lm.51202
Source: PubMed

ABSTRACT

One of the most rigorously investigated problems in modern neuroscience is to decipher the mechanisms by which experience-induced changes in the central nervous system are translated into behavioral acquisition, consolidation, retention, and subsequent recall of information. Brain-derived neurotrophic factor (BDNF) has recently emerged as one of the most potent molecular mediators of not only central synaptic plasticity, but also behavioral interactions between an organism and its environment. Recent experimental evidence indicates that BDNF modulates synaptic transmission and plasticity by acting across different spatial and temporal domains. BDNF signaling evokes both short- and long-term periods of enhanced synaptic physiology in both pre- and postsynaptic compartments of central synapses. Specifically, BDNF/TrkB signaling converges on the MAP kinase pathway to enhance excitatory synaptic transmission in vivo, as well as hippocampal-dependent learning in behaving animals. Emerging concepts of the intracellular signaling cascades involved in synaptic plasticity induced through environmental interactions resulting in behavioral learning further support the contention that BDNF/TrkB signaling plays a fundamental role in mediating enduring changes in central synaptic structure and function. Here we review recent literature showing the involvement of BDNF/TrkB signaling in hippocampal-dependent learning paradigms, as well as in the types of cellular plasticity proposed to underlie learning and memory.

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Available from: Lucas Pozzo-Miller, Dec 17, 2013
    • "These findings indicate the possibility that music has some effects on neuronal plasticity that is more efficient at early developmental stages. Brain-derived neurotrophic factor (BDNF) and its receptor TrkB are known to play a critical role in the synaptic plasticity underlying the acquisition and/or consolidation of certain forms of memory in both the developing and adult mammalian central nervous system (Tyler et al., 2002; Heldt et al., 2007). Correlational studies show that BDNF expression is increased in hippocampal-dependent tasks (Hall et al., 2000 ). "
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    ABSTRACT: Previous research has shown that dorsal hippocampus plays an important role in spatial memory process. Music exposure can enhance brain-derived neurotrophic factor (BDNF) expression level in dorsal hippocampus (DH) and thus enhance spatial cognition ability. But whether music experience may affect different subregions of DH in the same degree remains unclear. Here, we studied the effects of exposure to Mozart K.448 on learning behavior in developing rats using the classical Morris water maze task. The results showed that early music exposure could enhance significantly learning performance of the rats in the water maze test. Meanwhile, the BDNF/TrkB level of dorsal hippocampus CA3 (dCA3) and dentate gyrus (dDG) was significantly enhanced in rats exposed to Mozart music as compared to those without music exposure. In contrast, the BDNF/TrkB level of dorsal hippocampus CA1 (dCA1) was not affected. The results suggest that the spatial memory improvement by music exposure in rats may be associated with the enhanced BDNF/TrkB level of dCA3 and dDG.
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    • "This mature neurotrophin binds to protein-kinase neurotrophin receptors – tropomyosinerelated kinase (Trk) receptors. BDNF is crucial to learning and memory, since it regulates LTD (long-term depression) and LTP (long-term potentiation), synaptic plasticity, axonal sprouting, proliferation of dendritic arbor, and neuronal differentiation [12] [13]. These "
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    ABSTRACT: Aging is a normal physiological process accompanied by cognitive decline. This aging process has been the primary risk factor for development of aging-related diseases such as Alzheimer's disease (AD). Cognitive deficit is related to alterations of neurotrophic factors level such as brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF) and glial cell-derived neurotrophic factor (GDNF). These strong relationship between aging and AD is important to investigate the time which they overlap, as well as, the pathophysiological mechanism in each event. Considering that aging and AD are related to cognitive impairment, here we discuss the involving these neurotrophic factors in the aging process and AD.
    Preview · Article · Oct 2015 · Aging and Disease
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    • "BDNF is a growth factor recognised for its involvement in brain plasticity and as a regulator of neural growth, survival and function[23]. As such, it is involved in the control of numerous aspects of emotional and cognitive behaviours, such hippocampal-dependent learning[24]. Similarly, NMDA receptors are involved in memory formation through the control of synaptic plasticity[25]. "

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