Long-term prognostic significance of isolated minor electrocardiographic T-wave abnormalities in middle-aged men free of clinical cardiovascular disease (The Multiple Risk Factor Intervention Trial [MRFIT])
The presence or new onset of isolated minor T-wave abnormalities (Minnesota Code 5.3 or 5.4) associated with a greater spatial T-axis deviation was shown to be independently predictive of long-term (18.5 years) cardiovascular disease and coronary heart disease mortality. This was tested in a cohort of >11,000 middle-aged men who were free of clinical coronary heart disease in the Multiple Risk Factor Interventional Trial.
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