Article

Anti-inflammatory effects of aqueous extract from Dichroa febrifuga root in rat liver

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Abstract

To study the anti-inflammatory effects of aqueous extract from Dichroa febrifuga root (AEDF) for suppression in the process of lipopolysaccharide (LPS)-induced sepsis in the rat liver. The inhibitory effect of AEDF on the alteration of inflammatory proteins was investigated by Western blot and immunohistochemical analysis. Western blot analysis showed that the level of nuclear factor (NF)-kappaBp65 was markedly up-regulated and (I)-kappaBalpha was down-regulated by LPS (8 mg/kg) challenge. However, AEDF 100 mg/kg inhibited induction of NF-kappaBp65 and degradation of I-kappaBalpha in the liver of LPS-challenged rats. Immunohistochemical analysis showed that while the expression of the NF-kappaBp65, tumor necrosis factor (TNF)-alpha and inducible nitric oxide synthase (iNOS) tended to increase, that of I-kappaBalpha was decreased in the hepatocytes of rats challenged with LPS. A slight decline of NF-kappaBp65, TNF-alpha and iNOS, but an increase of I-kappaBalpha were observed in the hepatocytes of the rats pretreated with AEDF. AEDF may act as a therapeutic agent for inflammatory disease through a regulation of inflammation-related proteins.

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... Bahkan, jenis tersebut juga dimanfaatkan sebagai obat batuk di China dan Korea. Selain itu, D. febrifuga juga dimanfaatkan sebagai bahan pelengkap pengobatan demam yang disebabkan oleh infeksi (Choi et al., 2003). Ekstrak akar D. ferbrifuga juga dapat dikembangkan sebagai obat anti inflamasi (Kim et al., 2000). ...
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