Quantitative assessment of tumor oxygen dynamics: Molecular imaging for prognostic radiology

Department of Radiology, U.T. Southwestern Medical Center, Dallas, Texas, USA.
Journal of cellular biochemistry. Supplement 01/2002; 39(S39):45-53. DOI: 10.1002/jcb.10404
Source: PubMed


One of the fundamental molecules governing the survival of mammalian cells is oxygen. Oxygen has gained particular significance in tumor developmental biology and oncology. An increasingly diverse array of methods is now available to characterize tumor oxygenation. This Prospect will consider a new method, Fluorocarbon Relaxometry using Echo planar imaging for Dynamic Oxygen Mapping (FREDOM), which we have recently developed for oximetry, examine application to a specific therapeutic example and place this technique in the context of other approaches.

Download full-text


Available from: Sophia Ran
  • Source
    • "and/or non-invasive methods of examining the function of tumor vasculature, such as blood flow and tissue perfusion measurements [Mason et al., 2002]. "
    [Show abstract] [Hide abstract]
    ABSTRACT: Pancreatic cancer is a major unsolved health problem. The estimated overall 5-year survival rate of only 1-4% is due to aggressiveness of the disease and the lack of effective systemic therapies. Most pancreatic cancer-related deaths are due to the development of metastases, which represents the culmination of a complex interaction between the host organism and neoplastic cells within the primary tumor. Therefore, the study of tumor-host interaction in the context of the whole organism is necessary to evaluate the pathogenesis of tumor growth and metastasis so that effective therapies can be developed. Recent advances in functional imaging combined with animal models that faithfully recreate the biology of human tumors have elevated our ability to examine these complex interactions. In this review, we will use the example of orthotopic mouse models of pancreatic cancer as a tool to survey the challenges and possibilities of functional imaging of angiogenesis, a critical determinant of metastasis.
    Full-text · Article · Oct 2003 · Journal of Cellular Biochemistry
  • Source

    Preview · Article ·
  • [Show abstract] [Hide abstract]
    ABSTRACT: Three oxygen-sensitive parameters (arterial hemoglobin oxygen saturation SaO2, tumor vascular oxygenated hemoglobin concentration [HbO2], and tumor oxygen tension pO2) were measured simultaneously by three different optical techniques (pulse oximeter, near infrared spectroscopy, and FOXY) to evaluate dynamic responses of breast tumors to carbogen (5% CO2 and 95% O2) intervention. All three parameters displayed similar trends in dynamic response to carbogen challenge, but with different response times. These response times were quantified by the time constants of the exponential fitting curves, revealing the immediate and the fastest response from the arterial SaO2, followed by changes in global tumor vascular [HbO2], and delayed responses for pO2. The consistency of the three oxygen-sensitive parameters demonstrated the ability of NIRS to monitor therapeutic interventions for rat breast tumors in-vivo in real time.
    No preview · Article · Jan 2003 · Proceedings of SPIE - The International Society for Optical Engineering
Show more