Article

Radiopharmaceuticals: New antimicrobial agents

Università di Pisa, Pisa, Tuscany, Italy
Trends in Biotechnology (Impact Factor: 11.96). 03/2003; 21(2):70-3. DOI: 10.1016/S0167-7799(02)00032-X
Source: PubMed

ABSTRACT

Small antimicrobial peptides are good candidates for new antimicrobial agents. A scintigraphic approach to studying the pharmacokinetics of antimicrobial peptides in animals has been developed. The peptides were safely and reproducibly labelled with technetium-99m and, after intravenous injection of the radiolabelled peptides into infected animals, scintigraphy allowed real-time quantification of the peptide in the various body compartments. Antimicrobial peptides rapidly accumulated at sites of infection but not at sites of sterile inflammation, indicating that radiolabelled antimicrobial peptides could be used in detection of infection. These radiopharmaceuticals enabled the efficacy of antibacterial therapy in animals to be monitored. The scintigraphic approach provides a useful method for investigating the pharmacokinetics of small peptides in animals.

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Available from: Antonella Lupetti
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    • "Recently, the binding of one specific (radiolabeled) synthetic fragment from UBI to various bacteria and fungi was established and enabled accumulation and visualization of experimental infections [18] [19] and the monitoring of antimicrobial therapy [14]. The observation that the synthetic fragments of UBI target to infection sites [12] opens perspectives for antimicrobial treatment with UBI derived peptides in patients [1] [13]. UBI 1–59 is of human origin and is not expected to be immunogenic for man and resistance induction is expected to be significantly lower than for classical antibiotics. "
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