First live birth after ovarian stimulation using a chimeric long-acting human recombinant follicle-stimulating hormone (FSH) agonist (recFSH-CTP) for in vitro fertilization

ArticleinFertility and Sterility 79(3):621-3 · April 2003with4 Reads
Impact Factor: 4.59 · DOI: 10.1016/S0015-0282(02)04804-5 · Source: PubMed

    Abstract

    To report the first pregnancy and live birth after ovarian stimulation using a chimeric long-acting human recombinant FSH agonist (recFSH-CTP) for IVF.
    Case report.
    Tertiary fertility center.
    A 32-year-old woman with a 7-year history of primary infertility.
    Ovarian stimulation with a single SC injection of 180 microg recFSH-CTP on cycle day 3, followed by daily injections of 150 IU recFSH from cycle day 10 onward, combined with daily GnRH antagonist 0.25 mg SC to prevent a premature LH rise. Final oocyte maturation was induced by 10,000 IU hCG.
    First ongoing pregnancy obtained with recFSH-CTP.
    Twelve oocytes were retrieved. Ten oocytes were fertilized in vitro by intracytoplasmic sperm injection, and from these 10 oocytes, two embryos were subsequently transferred after 3 days of culture. A pregnancy test 2 weeks after ET was positive, and ultrasound investigation revealed an intact, intrauterine, singleton pregnancy after 12 weeks.
    The first pregnancy and live birth was achieved after ovarian stimulation using recFSH-CTP for IVF.