Micellar nanocontainers distribute to defined cytoplasmic organelles. Science

ArticleinScience 300(5619):615-8 · May 2003with29 Reads
Impact Factor: 33.61 · DOI: 10.1126/science.1078192 · Source: PubMed

    Abstract

    Block copolymer micelles are water-soluble biocompatible nanocontainers with great potential for delivering hydrophobic drugs.
    An understanding of their cellular distribution is essential to achieving selective delivery of drugs at the subcellular level.
    Triple-labeling confocal microscopy in live cells revealed the localization of micelles in several cytoplasmic organelles,
    including mitochondria, but not in the nucleus. Moreover, micelles change the cellular distribution of and increase the amount
    of the agent delivered to the cells. These micelles may thus be worth exploring for their potential to selectively deliver
    drugs to specified subcellular targets.